This is a revised, competing renewal application for a highly successful Center of Comparative Respiratory Biology and Medicine (CCRBM) T32 program that has trained more than 120 pre- doctoral students and post-doctoral scholars in lung biology and medicine over the last 39 years. The objective of this pre- and post-doctoral program is to train the next generation of scientists through interdisciplinary research and coursework that addresses issues of direct relevance to the NHLBI mission. We are requesting (annually) funds for two years of support for each of 6 pre-doctoral and 3 post-doctoral trainees recruited from several UC Davis graduate programs and departments that provide disciplinary training relevant to lung health, including pharmacology, toxicology, cell and molecular biology, informatics, engineering, epidemiology, immunology and genetics. Training faculty- 35 active researchers from 12 departments- have substantial experience mentoring students. Faculty preceptors will direct research training in four primary areas: 1) Lung Immunology and the Airway Epithelium 2) Engineering and Informatics in Lung Medicine; 3) Lung Health and the Environment; 4) Translational Research and Therapeutics. Significant interactions among our training faculty members promote interdisciplinary approaches to lung research. Trainees have access to advanced technologies, such as proteomics, epi/genomics, breath metabolomics, state- of-the-art imaging, genetically modified organisms, and inhalation facilities for rodents and non- human primates. Molecular, cellular, tissue, and diverse animal models, including nonhuman primate models, complement human studies from faculty in the Division of Pulmonary, Critical Care, and Sleep Medicine and the Center for Comparative Respiratory Biology and Medicine. The training program leverages the activities and resources of multiple research centers at UC Davis to provide synergy and promote connections to disease prevention and public health; examples include the Clinical and Translational Science Center, the Environmental Health Sciences Center at UC Davis, the NCI Comprehensive Cancer Center, the California National Primate Research Center, the NIH Mouse biology program, the Genome Center, and the NIH-designated West Coast Metabolomics Center. The training program also emphasizes practical instruction in scientific writing and communication of scientific findings to peers and lay audiences through chalk talks, town halls, and national meetings. Trainees are exposed to emerging concepts, controversies, and technologies in lung health by participating in the program?s research and training conferences including the weekly CCRBM seminar series, other specialized seminar series, and the annual ?Lung Day? retreat.

Public Health Relevance

The Training in Comparative Respiratory Biology and Medicine Program at UC Davis provides unique training in lung biology to pre-doctoral students and post-doctoral scholars to prepare them for diverse research careers focused on lung health. This program builds on existing interdisciplinary and collaborative research strengths at UC Davis, with integration of studies at the molecular, cellular, organismal, and human levels to better understand lung disease and improve treatments. Funds are requested to provide two years of support a total of nine pre- and post-doctoral trainees who will receive a combination of didactic and experiential training in current and emerging concepts in lung health.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007013-42
Application #
9977789
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Kalantari, Roya
Project Start
1975-07-01
Project End
2024-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
42
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of California Davis
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Bratt, Jennifer M; Chang, Kevin Y; Rabowsky, Michelle et al. (2018) Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation. J Immunol 200:3840-3856
Zamuruyev, Konstantin O; Borras, Eva; Pettit, Dayna R et al. (2018) Effect of temperature control on the metabolite content in exhaled breath condensate. Anal Chim Acta 1006:49-60
Zamuruyev, Konstantin O; Schmidt, Alexander J; Borras, Eva et al. (2018) Power-efficient self-cleaning hydrophilic condenser surface for portable exhaled breath condensate (EBC) metabolomic sampling. J Breath Res 12:036020
Yamaguchi, Mei S; McCartney, Mitchell M; Linderholm, Angela L et al. (2018) Headspace sorptive extraction-gas chromatography-mass spectrometry method to measure volatile emissions from human airway cell cultures. J Chromatogr B Analyt Technol Biomed Life Sci 1090:36-42
Nguyen, Dan-Vinh; Linderholm, Angela; Haczku, Angela et al. (2017) Glucagon-like peptide 1: A potential anti-inflammatory pathway in obesity-related asthma. Pharmacol Ther 180:139-143
Takada, Yoko K; Yu, Jessica; Fujita, Masaaki et al. (2017) Direct binding to integrins and loss of disulfide linkage in interleukin-1? (IL-1?) are involved in the agonistic action of IL-1?. J Biol Chem 292:20067-20075
Dela Pena-Ponce, Myra G; Jimenez, Monica T; Hansen, Lori M et al. (2017) The Helicobacter pylori type IV secretion system promotes IL-8 synthesis in a model of pediatric airway epithelium via p38 MAP kinase. PLoS One 12:e0183324
Carney, Randy P; Thillier, Yann; Kiss, Zsofia et al. (2017) Combinatorial Library Screening with Liposomes for Discovery of Membrane Active Peptides. ACS Comb Sci 19:299-307
Killingbeck, S S; Ge, M Q; Haczku, A (2017) Patching it together: epicutaneous vaccination with heat-labile Escherichia coli toxin against birch pollen allergy. Allergy 72:5-8
Aksenov, Alexander A; Zamuruyev, Konstantin O; Pasamontes, Alberto et al. (2017) Analytical methodologies for broad metabolite coverage of exhaled breath condensate. J Chromatogr B Analyt Technol Biomed Life Sci 1061-1062:17-25

Showing the most recent 10 out of 104 publications