This multidisciplinary, 25-year training program is designed to develop independent scientists competent to critically utilize the principles of basic and clinical cardiovascular research to improve therapeutic strategies designed to alleviate and prevent cardiovascular disease. Its centerpiece is the intense and sustained training in cardiovascular research of each trainee for a 2-year minimum in a research project supervised by a faculty preceptor. During the current grant interval the Cardiology Division acquired 10,000-sq. ft. of additional laboratory space and created the Center for Cardiovascular Research. Washington University established a Master of Science in Clinical Investigation Program. These changes led to recruitment of additional research faculty, increased scientific collaborations among, program faculty, and strengthened the research training program. The 22 preceptors from 14 departments/divisions are experienced in conveying principles underlying effective basic and clinical research as well as techniques needed to trainees in their laboratories. They have expertise in biochemistry; biostatistics; bioengineering; cardiovascular medicine; cell, molecular, and vascular biology; computer sciences; epidemiology; pathology; pharmacology; physics; physiology; radiology-, and surgery. They share interests and link basic and clinical research in themes focused on arrhythmogenesis; atherosclerosis, vascular biology, and coagulation; molecular basis and genetics of human cardiac disease; myocardial metabolism, perfusion, and function; cardiovascular imaging; and epidemiology and outcomes assessment. Each trainee participates in a core curriculum on biostatistics, ethical issues in research, scientific integrity, manuscript and grant preparation, and laboratory safety; workshops that provide in-depth training in each of the major investigative areas; research seminars; and elective course work keyed to each trainee's research area. This program has been consistently oversubscribed with highly qualified candidates. Candidates for the 8 positions requested each year will be selected based on past achievements and the likelihood they will pursue an academic research career.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007081-29
Application #
6769948
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Commarato, Michael
Project Start
1975-07-01
Project End
2006-05-31
Budget Start
2004-06-01
Budget End
2005-05-31
Support Year
29
Fiscal Year
2004
Total Cost
$188,327
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Williams, Jesse W; Martel, Catherine; Potteaux, Stephane et al. (2018) Limited Macrophage Positional Dynamics in Progressing or Regressing Murine Atherosclerotic Plaques-Brief Report. Arterioscler Thromb Vasc Biol 38:1702-1710
Rimer, Jamie M; Lee, Jiyeon; Holley, Christopher L et al. (2018) Long-range function of secreted small nucleolar RNAs that direct 2'-O-methylation. J Biol Chem 293:13284-13296
Coverstone, Edward D; Bach, Richard G; Chen, LiShiun et al. (2018) A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction. Basic Res Cardiol 113:38
Johnson, Eric K; Springer, Steven J; Wang, Wei et al. (2018) Differential Expression and Remodeling of Transient Outward Potassium Currents in Human Left Ventricles. Circ Arrhythm Electrophysiol 11:e005914
Johnson, Eric K; Matkovich, Scot J; Nerbonne, Jeanne M (2018) Regional Differences in mRNA and lncRNA Expression Profiles in Non-Failing Human Atria and Ventricles. Sci Rep 8:13919
Hartupee, Justin; Patel, Rohan; Staloch, Lora et al. (2017) Diagnostic accuracy of damage-associated molecular patterns (DAMPs) in patients with heart failure with a reduced ejection fraction. J Clin Transl Sci 1:208-209
Mangold, Kathryn E; Brumback, Brittany D; Angsutararux, Paweorn et al. (2017) Mechanisms and models of cardiac sodium channel inactivation. Channels (Austin) 11:517-533
Williams, Jesse W; Elvington, Andrew; Ivanov, Stoyan et al. (2017) Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood. Circ Res 121:662-676
Adamo, Luigi; Nassif, Michael E; Novak, Erik et al. (2017) Prevalence of lactic acidaemia in patients with advanced heart failure and depressed cardiac output. Eur J Heart Fail 19:1027-1033
Liu, Haiyan; Javaheri, Ali; Godar, Rebecca J et al. (2017) Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway. Autophagy 13:1952-1968

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