The Hematology Research Training Program at the University of Washington is designed to provide intensive post-doctoral research training in investigative hematology. The program emphasizes cell and molecular biology, with particular strengths in: stem cells and hematopoiesis, cell and gene therapy, platelets and hemostasis, vascular biology, hematologic malignancies, cancer biology, and hematopoietic cell transplantation. Program faculty include established investigators with strong independent research programs from both basic science and clinical departments of the University of Washington. The faculty is based at the University of Washington campuses, the Fred Hutchinson Cancer Research Center, and nearby affiliated institutions. The goal of the training program is to develop the research, presentation, and fund-raising skills that trainees will need to establish independent research careers, and to train future leaders in the field of research hematology. Trainees have MD, MD/PhD or PhD degrees. Many have completed clinical training in hematology, but others are basic researchers wishing to work in the field. Trainees are chosen through an application process and interactions with program faculty. They obtain research experience by working with a mentor, and are assisted in laboratory techniques, data analysis, publishing papers, presentation skills, and acquiring independent grant support. Trainees typically receive 2 years of funding from the program, but often continue their training longer under separate funding mechanisms. Training progress is monitored by the faculty mentor, a separate faculty advisor, the Program Directors, and the Division of Hematology faculty through regular research presentations, meetings with each trainee, and written evaluations. Strengths of the program include: diverse research opportunities, a qualified senior faculty, the inclusion of under-represented minority trainees, and a long track record spanning over five decades of training graduates that subsequently obtained junior faculty positions and became independent and distinguished investigators.

Public Health Relevance

There continues to be a need for trained scientists, particularly physician-scientists, in the field of hematology, as this discipline is at the forefront of modern medicine. This grant will support the training of hematology researchers at a critical time in their careers - the transition from post-doctoral fellow to independent investigator - and develop scientists that will advance hematology and health care in the USA.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007093-43
Application #
9295053
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Chang, Henry
Project Start
1975-07-01
Project End
2020-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
43
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Hart, Matthew R; Anderson, Donovan J; Porter, Christopher C et al. (2018) Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations. PLoS Genet 14:e1007642
Schmitt, Michael W; Pritchard, Justin R; Leighow, Scott M et al. (2018) Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive Leukemias. Clin Cancer Res 24:5321-5334
Samuelson Bannow, B T; Konkle, B A (2018) Laboratory biomarkers for venous thromboembolism risk in patients with hematologic malignancies: A review. Thromb Res 163:138-145
Wang, Tzu-Fei; Li, Ang; Garcia, David (2018) Managing thrombosis in cancer patients. Res Pract Thromb Haemost 2:429-438
Appelbaum, Jacob; Wells, David; Hiatt, Joseph B et al. (2018) Fatal enteric plexus neuropathy after one dose of ipilimumab plus nivolumab: a case report. J Immunother Cancer 6:82
Correnti, Colin E; Laszlo, George S; de van der Schueren, Willem J et al. (2018) Simultaneous multiple interaction T-cell engaging (SMITE) bispecific antibodies overcome bispecific T-cell engager (BiTE) resistance via CD28 co-stimulation. Leukemia 32:1239-1243
Li, A; Khalighi, P R; Wu, Q et al. (2018) External validation of the PLASMIC score: a clinical prediction tool for thrombotic thrombocytopenic purpura diagnosis and treatment. J Thromb Haemost 16:164-169
Appelbaum, Jacob S; Milano, Filippo (2018) Hematopoietic Stem Cell Transplantation in the Era of Engineered Cell Therapy. Curr Hematol Malig Rep 13:484-493
Poston, Jacqueline N; Dorer, Russell; Aboulafia, David M (2018) The Diving Bell and the Butterfly Revisited: A Fatal Case of Locked-in Syndrome in a Man With Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified. Clin Med Insights Blood Disord 11:1179545X18762799
Buckley, Sarah A; Percival, Mary-Elizabeth; Othus, Megan et al. (2018) A comparison of patients with acute myeloid leukemia and high-risk myelodysplastic syndrome treated on versus off study. Leuk Lymphoma :1-7

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