Duke University Medical Center has been engaged in the training of clinicians and scientists in the area of cardiovascular diseases -for over 40 years. Much of this success can be attributed to 25 years of funding of the Cardiovascular Training Program Grant. This application is a competitive renewal for our Cardiovascular Training Program Grant, which was last funded in 1996. The cardiovascular training program represents the integrated efforts of the Departments of Medicine, Surgery, Cell Biology, Pediatrics, Pharmacology, Engineering, and Genetics to train postdoctoral cardiovascular physician-scientists. This will be accomplished by providing a multidisciplinary faculty and environment to trainees in order to foster and develop excellence in biomedical research related to the cardiovascular system. The underlying philosophy of this program will be to integrate training and research by creating an environment that facilitates the natural linkages among programs and departments throughout the University. An extended period of research (2 years or more) will be provided to trainees under the mentorship of program faculty who will closely supervise and direct the academic career development of the trainee. This program will provide an important mechanism for supporting trainees during a critical period of postgraduate medical training and provide an environment conducive to a research-oriented career. During this time, trainees will be """"""""protected"""""""" from clinical responsibilities and immersed in research to obtain the background and experience necessary to establish themselves an independent investigators in academic institutions. The individual mentor will provide skills such as experimental design, data analysis, and manuscript and grant preparation during the training period. The goal of this program is to continue this history of productivity by creating an environment that will ensure that Duke will continue to contribute to the development of young investigators capable of pursuing successful research careers in cardiovascular fields. The current application will describe the modifications and improvements that have been recently implemented and will discuss Duke""""""""s ongoing commitment to train the next generation of cardiovascular researchers. The training program emphasizes the training of physician-scientists, and to this end, approximately 90% of the trainees will be MDs or MD/PhDs.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007101-26
Application #
6313917
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Schucker, Beth
Project Start
1975-07-01
Project End
2006-03-31
Budget Start
2001-04-01
Budget End
2002-03-31
Support Year
26
Fiscal Year
2001
Total Cost
$446,801
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Fudim, Marat; Jones, W Schuyler; Boortz-Marx, Richard L et al. (2018) Splanchnic Nerve Block for Acute Heart Failure. Circulation 138:951-953
Mokalled, Mayssa H; Poss, Kenneth D (2018) A Regeneration Toolkit. Dev Cell 47:267-280
Wang, Yingxue; Christopher, Bridgette A; Wilson, Kirkland A et al. (2018) Propionate-induced changes in cardiac metabolism, notably CoA trapping, are not altered by l-carnitine. Am J Physiol Endocrinol Metab 315:E622-E633
Fudim, Marat; Mentz, Robert J (2018) Early versus late readmission during the vulnerable phase following hospitalization for heart failure: reply. Eur J Heart Fail 20:1166
Bu, Pengcheng; Chen, Kai-Yuan; Xiang, Kun et al. (2018) Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis. Cell Metab 27:1249-1262.e4
Ahn, Seungkirl; Pani, Biswaranjan; Kahsai, Alem W et al. (2018) Small-Molecule Positive Allosteric Modulators of the ?2-Adrenoceptor Isolated from DNA-Encoded Libraries. Mol Pharmacol 94:850-861
McGarrah, Robert W; Crown, Scott B; Zhang, Guo-Fang et al. (2018) Cardiovascular Metabolomics. Circ Res 122:1238-1258
Fudim, Marat; Liu, Peter R; Shrader, Peter et al. (2018) Mineralocorticoid Receptor Antagonism in Patients With Atrial Fibrillation: Findings From the ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) Registry. J Am Heart Assoc 7:
Kleiner Shochat, Michael; Fudim, Marat; Shotan, Avraham et al. (2018) Prediction of readmissions and mortality in patients with heart failure: lessons from the IMPEDANCE-HF extended trial. ESC Heart Fail 5:788-799
Fudim, Marat; O'Connor, Christopher M; Mulder, Hillary et al. (2018) Loop diuretic adjustments in patients with chronic heart failure: Insights from HF-ACTION. Am Heart J 205:133-141

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