The mission of the ?Cardiovasology? Training Program at Mayo Clinic is to address national needs in developing, diversifying, and sustaining the next generation workforce in cardiovascular science and medicine, and from whom new leaders in this multidisciplinary field will emerge. The renewal, for years 41 to 45, builds on a legacy of excellence with demonstrated track-records in scientific proficiency and productivity, extramural support and academic placement, contributing to the nation?s best practices for the betterment of health. Drawing from the highest educational standards and cutting-edge technological platforms, ?Cardiovasology? is customized to match the background and career path of each trainee providing opportunities to widen interests and expand capabilities in pursuit of evolving scientific advances. Heart failure is the central theme, informed by morbidity and mortality trends. The interactive, diverse faculty of 32 funded subject matter experts from 11 departments, with robust mentoring records, enables team-science training across basic, translational, clinical and population science tracks. Spanning tracks, curricula are practical, relevant and timely, and focus on application of research methods to address patient needs optimizing the trainee's ability to challenge, refine or create paradigms. Newly established local/regional/national transdisciplinary synergies expedite high- throughput discovery and data mining, disease model interrogation, clinical trial execution, health disparities research, and community outcomes. Program strength rests in leveraging Mayo Clinic investments in state-of- the-art infrastructures and institutional priorities in individualized medicine, regenerative medicine, and science of health care delivery, expanding the means for novel diagnostics, prognostics and therapeutics. Content in disruptive innovation and deep learning (including artificial intelligence, augmented reality, advanced biotherapies), and prominence in product development, regulatory science, and bio-business, further equip trainees with the readiness to apply new know-how to combat heart failure burden and actuate the NHLBI Strategic Plan. The renewal capitalizes on degree-granting programs, and attracts highly competitive MD, MD/PhD, and PhD candidates from across the nation with a recognized emphasis on participation of women. A history of strong recruitment and retention, supplemented with a fellow-to-faculty career development program, has fostered the stepwise launch of competitive independent careers. Accordingly, ?Cardiovasology? requests the continuous support for six postdoctoral trainees. Committed to a community of diversity to attract high quality candidates, provide trainees with essential skillsets and new competencies, the Program actively builds the workforce of the future supplying the pipeline to meet a 2030 trajectory. The renewal underscores the creative, innovative and dynamic vision of the ?Cardiovasology? Training Program empowering the emerging academic cadre to lead the way in turning science into cardiovascular health.

Public Health Relevance

The ?Cardiovasology? Training Program at Mayo Clinic is an avenue for advanced training of the specialized workforce of physicians/scientists focused on heart health and disease. This proposal expands Program faculty and scope, deepens and broadens its scientific expertise, fosters diversity of mentors and trainees, and integrates new training in emerging technologies and innovations. This Program builds on a four-decades long history of excellence in attracting, mentoring and retaining talented individuals that will form the next generation of science leaders and scholars in this country.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007111-41
Application #
9852779
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Wang, Wayne C
Project Start
1975-07-01
Project End
2025-03-31
Budget Start
2020-04-01
Budget End
2021-03-31
Support Year
41
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Reddy, Yogesh N V; Olson, Thomas P; Obokata, Masaru et al. (2018) Hemodynamic Correlates and Diagnostic Role of Cardiopulmonary Exercise Testing in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail 6:665-675
Khorramirouz, Reza; Go, Jason L; Noble, Christopher et al. (2018) A novel surgical technique for a rat subcutaneous implantation of a tissue engineered scaffold. Acta Histochem 120:282-291
Reddy, Yogesh N V; Obokata, Masaru; Gersh, Bernard J et al. (2018) High Prevalence of Occult Heart Failure With Preserved Ejection Fraction Among Patients With Atrial Fibrillation and Dyspnea. Circulation 137:534-535
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Tefft, Brandon J; Uthamaraj, Susheil; Harbuzariu, Adriana et al. (2018) Nanoparticle-Mediated Cell Capture Enables Rapid Endothelialization of a Novel Bare Metal Stent. Tissue Eng Part A 24:1157-1166
Choe, Joshua A; Jana, Soumen; Tefft, Brandon J et al. (2018) Biomaterial characterization of off-the-shelf decellularized porcine pericardial tissue for use in prosthetic valvular applications. J Tissue Eng Regen Med 12:1608-1620
Bell, Elizabeth J; Decker, Paul A; Tsai, Michael Y et al. (2018) Hepatocyte growth factor is associated with progression of atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 272:162-167
Reddy, Yogesh N V; El Sabbagh, Abdallah; Packer, Douglas et al. (2018) Evaluation of shortness of breath after atrial fibrillation ablation-Is there a stiff left atrium? Heart Rhythm 15:930-935
Egbe, Alexander C; Reddy, Yogesh N V; Khan, Arooj R et al. (2018) Venous congestion and pulmonary vascular function in Fontan circulation: Implications for prognosis and treatment. Int J Cardiol 271:312-316
Reddy, Yogesh N V; Carter, Rickey E; Obokata, Masaru et al. (2018) A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction. Circulation 138:861-870

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