The program objective is to train promising new scientists in mechanisms of cardiovascular diseases, experimental strategies and technologies necessary for development of novel molecular therapeutics. The theme of the program is signal transduction within a multidisciplinary, integrated program that focuses on molecular events in cardiovascular development, proteomics, cardiac stem cells and regenerative medicine as well as the molecular basis of cardiovascular disease. Future decades will see rapid advances in our understanding of the structure and function of molecules involved in cardiovascular disease and hopefully the successful application of these insights into the development of novel treatments and prevention of cardiovascular diseases. Such advances will require well-trained, energetic and productive scientists with the ability to understand and manipulate molecular events within a physiological context. These are the type of individuals that we intend to develop through the integrated predoctoral and postdoctoral components of this training program. The 36 mentor-eligible faculty members were selected on the basis of their research interests related to cardiovascular diseases, active NIH research support, ongoing collaborations, successful training and mentoring experience, and commitment to predoctoral and postdoctoral training. The Program Director and Co-Director are assisted by a Program Steering Committee and an External Advisory Committee of outstanding experts in the field of cardiovascular biology. Key components of the training program are the mentor research experience, required didactic courses providing a broad perspective of cardiovascular disease, required training and responsible conduct of research, elective courses, cardiovascular journal club, seminars, presentations at regional and national conferences, and professional development activities. The cardiovascular journal club, seminars, workshops, student research day, and annual cardiovascular retreat provide a framework for all trainees to interact, collaborate, and work together during their training experience. An integrative, multi-year evaluation plan is used to measure the extent to which the program goals and objectives are met.
Our aim i s to produce outstanding investigators with a broad insight into cardiovascular dysfunction who make significant contributions to the understanding of these disorders and development of therapies for cardiovascular diseases.
/ PUBLIC HEALTH RELEVANCE The need for a highly trained workforce to address the treatment of cardiovascular disease continues to increase. Major demographic changes resulting from an aging population, elderly with chronic disease, and obesity are leading to increases in risk for cardiovascular events;interventional therapies and increasing survival rates are requiring more specialized treatments and follow-ups;and new technologies methodologies are requiring additional training in sophisticated procedures. This training grant will help train the next generation of scientists and clinician scientists engaged in cardiovascular research.
| Kimbrough, Denise; Wang, Sabina H; Wright, Lillianne H et al. (2018) HDAC inhibition helps post-MI healing by modulating macrophage polarization. J Mol Cell Cardiol 119:51-63 |
| Cheng, Qi; Patel, Kunal; Lei, Biao et al. (2018) Donor pretreatment with nebulized complement C3a receptor antagonist mitigates brain-death induced immunological injury post-lung transplant. Am J Transplant 18:2417-2428 |
| Tran, Danh T; Esckilsen, Scott; Mulligan, Jennifer et al. (2018) Impact of Mitochondrial Permeability on Endothelial Cell Immunogenicity in Transplantation. Transplantation 102:935-944 |
| Wright, Lillianne H; Herr, Daniel J; Brown, Symone S et al. (2018) Angiokine Wisp-1 is increased in myocardial infarction and regulates cardiac endothelial signaling. JCI Insight 3: |
| Herr, Daniel J; Baarine, Mauhamad; Aune, Sverre E et al. (2018) HDAC1 localizes to the mitochondria of cardiac myocytes and contributes to early cardiac reperfusion injury. J Mol Cell Cardiol 114:309-319 |
| Stephenson, Sarah E; Wilson, Carole L; Crothers, Kristina et al. (2018) Impact of HIV infection on ?1-antitrypsin in the lung. Am J Physiol Lung Cell Mol Physiol 314:L583-L592 |
| Arbra, Chase A; Fann, Stephen A (2017) Parastomal Evisceration: Rare Complication after Total Abdominal Colectomy. Am Surg 83:379-380 |
| Richards, Dylan; Jia, Jia; Yost, Michael et al. (2017) 3D Bioprinting for Vascularized Tissue Fabrication. Ann Biomed Eng 45:132-147 |
| Richards, Dylan J; Coyle, Robert C; Tan, Yu et al. (2017) Inspiration from heart development: Biomimetic development of functional human cardiac organoids. Biomaterials 142:112-123 |
| Toomer, Katelynn A; Fulmer, Diana; Guo, Lilong et al. (2017) A role for primary cilia in aortic valve development and disease. Dev Dyn 246:625-634 |
Showing the most recent 10 out of 123 publications
