This Training Program, Mechanisms of Hypertension and Cardiovascular Diseases, Suzanne Oparil, MD, PD/PI, offers multidisciplinary postdoctoral training in fundamental aspects of the pathophysiology of hypertension and related cardiovascular disease (CVD), in innovative approaches to the diagnosis and treatment of these conditions and in translating basic and clinical research findings to the population level. This Training Program advances the spectrum of available training in the following Thematic Focus Areas: Basic Science (fundamental training in mechanisms of inflammatory vascular injury and repair and oxidative stress/free radical injury; T0); Translational Science (translation-to-humans, early clinical trials, testing basic science discoveries for clinical applicability; T1-T2) Clinica Science (research to improve knowledge of new therapies, medical applications and clinical interventions; T2-T3), and Population Science (clinical trials to wide-spread evidence-based practice that improves the overall public health; T3-T4). Faculty Mentors offer training in these rapidly evolving research areas: behavioral, epidemiologic and population/prevention research, state-of-the-art clinical trials, comparative effectiveness research, biostatistics/quantitative sciences, genomics, health disparities research, other-Omics, and regenerative and reparative medicine. Trainees will have a 2-3 year experience in laboratory, clinical/translational or population- based research under the mentorship of T32 Program Faculty Mentors. Trainees will spend at least 80% of time in investigation, coursework, and in career development activities. The goal of this Program is to prepare trainees for careers in fundamental, clinical, translational and population-based research in hypertension and CVD. The educational experiences available to our trainees will equip them with the technical skills and theoretical background needed to make them competitive for faculty positions in prestigious academic institutions, in the biotechnology/pharmaceutical industry or in health care delivery research. An important goal of this Training Program is to build productive, efficient, and cutting edge interdisciplinary research and training programs. Thus, this Program and its Faculty Mentors partner with the UAB Center for Clinical and Translational Science (CCTS). The mission of the UAB CCTS is to transform UAB's environment by building interdisciplinary research teams through educational ingenuity, regulatory reorganization, resource coordination, and methodological innovation. The UAB CCTS is one of 62 nationwide CTSA Centers, and the ONLY CTSA Program in Alabama. Relevance: There is a shortage of basic, translational, clinical and population scientists trained to use cutting edge approaches to problems related to hypertension and CVD, a leading cause of death and disability in the US. This is the only Training Program in Alabama that provides highly integrated bench to bedside postdoctoral training. The burden of cardiovascular disease (CVD) in the United States (US) is steadily increasing, in part due to the aging of the US population, increased prevalence of conditions such as diabetes, chronic kidney disease and the metabolic syndrome and the emergence of high-risk populations, i.e., racial/ethnic minorities such as African-Americans and Hispanics, and persons infected with HIV/AIDS. These increasing health needs underscore the importance of training basic scientists, clinical scientists and population scientists in an environment conduciv to multidisciplinary team research in order to test more effective approaches to the prevention and treatment of hypertension and related vascular disease and other comorbidities. This Training Program addresses these goals, and is the only postdoctoral Training Program in the state of Alabama with a primary focus on hypertension and CVD.

Public Health Relevance

The burden of cardiovascular disease (CVD) in the United States (US) is steadily increasing, in part due to the aging of the US population, increased prevalence of conditions such as diabetes, chronic kidney disease and the metabolic syndrome and the emergence of high-risk populations, i.e., racial/ethnic minorities such as African-Americans and Hispanics, and persons infected with HIV/AIDS. These increasing health needs underscore the importance of training basic scientists, clinical scientists and population scientists in an environment conducive to multidisciplinary team research in order to test more effective approaches to the prevention and treatment of hypertension and related vascular disease and other comorbidities. This Training Program addresses these goals, and is the only postdoctoral Training Program in the state of Alabama with a primary focus on hypertension and CVD.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007457-38
Application #
9503751
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Wang, Wayne C
Project Start
1980-07-01
Project End
2021-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
38
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Bromfield, Samantha G; Booth 3rd, John N; Loop, Matthew S et al. (2018) Evaluating different criteria for defining a complete ambulatory blood pressure monitoring recording: data from the Jackson Heart Study. Blood Press Monit 23:103-111
Oduk, Yasin; Zhu, Wuqiang; Kannappan, Ramaswamy et al. (2018) VEGF nanoparticles repair the heart after myocardial infarction. Am J Physiol Heart Circ Physiol 314:H278-H284
Loop, Matthew Shane; van Dyke, Melissa K; Chen, Ligong et al. (2018) Low Utilization of Beta-Blockers Among Medicare Beneficiaries Hospitalized for Heart Failure With Reduced Ejection Fraction. J Card Fail :
Siddiqui, Mohammed; Phillips, Robert A; Bursztyn, Michael et al. (2018) Case of Refractory Hypertension Controlled After Aortic and Mitral Valve Replacement and Coronary Artery Bypass Grafting. Hypertension 72:3-9
Gao, Ling; Gregorich, Zachery R; Zhu, Wuqiang et al. (2018) Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell-Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine. Circulation 137:1712-1730
Loop, Matthew Shane; McClure, Leslie A; Levitan, Emily B et al. (2018) Fine particulate matter and incident coronary heart disease in the REGARDS cohort. Am Heart J 197:94-102
Speed, Joshua S; Hyndman, Kelly A; Roth, Kaehler et al. (2018) High dietary sodium causes dyssynchrony of the renal molecular clock in rats. Am J Physiol Renal Physiol 314:F89-F98
Payne, Gregory A; Li, Jindong; Xu, Xin et al. (2017) The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac Rejection. Sci Rep 7:7563
Becker, Bryan K; Speed, Joshua S; Powell, Mackenzie et al. (2017) Activation of neuronal endothelin B receptors mediates pressor response through alpha-1 adrenergic receptors. Physiol Rep 5:
Gohar, Eman Y; Kasztan, Malgorzata; Becker, Bryan K et al. (2017) Ovariectomy uncovers purinergic receptor activation of endothelin-dependent natriuresis. Am J Physiol Renal Physiol 313:F361-F369

Showing the most recent 10 out of 206 publications