Sleep disorders are increasingly recognized to be common in the American population and to have important adverse consequences, not only on behavior with an increased risk of crashes but also on the cardiovascular system. Thus, sleep disorders are a major public health problem. This application is for renewal of a postdoctoral research training program for sleep research and research in sleep disorders at the University of Pennsylvania. The overall goals of the program are to train a cadre of independent investigators on these topics with a particular focus on physician-scientists. The training program has three distinct tracks: a) basic research, b) translational research, and c) patient-oriented research. Each track combines didactic training with an intense research experience working with a mentor(s). The program utilizes established Masters Degrees at the University of Pennsylvania to amplify what is provided by this particular program. The relevant Masters degrees are the Masters in Translational Research (Track 2) and the Masters in Clinical Epidemiology (Track 3). The program utilizes the infrastructure for research in sleep and its disorders that has been developed at the University of Pennsylvania by the interdisciplinary Center for Sleep and Circadian Neurobiology. This infrastructure is for both basic and clinical research and includes a dedicated 4-bedroom sleep research facility for studies in humans, including patients with specific sleep disorders. The program utilizes a group mentorship model and a mentorship committee is established for each trainee. Trainees are given specific training not only in sleep research but also in """"""""survival"""""""" skills, including how to write grants. Career counseling is provide to each trainee and many of the trainees go on to successful academic careers as independent investigators. The strengths of the program include: a) a stable, dedicated leadership;b) a large group of productive research-oriented faculty who work in a very collaborative fashion;c) strong institutional support;and d) major research funding for faculty to pursue research.
Sleep disorders are common in the United States population. Indeed, given the association between obesity and common sleep disorders such as sleep apnea, the prevalence of sleep disorders is increasing. While sleep disorders represent a major public health problem, there are a limited number of investigators in the new field of sleep medicine. This is particularly the case for physician-scientists pursuing state of the art research. This research training program is focused on developing a workforce of physician-scientists studying sleep and its disorders with a secondary goal of training PhD investigators from different backgrounds.
| Zhang, Shirley L; Yue, Zhifeng; Arnold, Denice M et al. (2018) A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux. Cell 173:130-139.e10 |
| Fox, Elliott C; Wang, Kairuo; Aquino, Melissa et al. (2018) Sleep debt at the community level: impact of age, sex, race/ethnicity and health. Sleep Health 4:317-324 |
| Gehrman, Philip; Gooneratne, Nalaka S; Brewster, Glenna S et al. (2018) Impact of Alzheimer disease patients' sleep disturbances on their caregivers. Geriatr Nurs 39:60-65 |
| Brewster, Glenna S; Riegel, Barbara; Gehrman, Philip R (2018) Insomnia in the Older Adult. Sleep Med Clin 13:13-19 |
| Gerstner, Jason R; Perron, Isaac J; Riedy, Samantha M et al. (2017) Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7. Sci Adv 3:e1602663 |
| Brown, Marishka K; Strus, Ewa; Naidoo, Nirinjini (2017) Reduced Sleep During Social Isolation Leads to Cellular Stress and Induction of the Unfolded Protein Response. Sleep 40: |
| Mak-McCully, Rachel A; Rolland, Matthieu; Sargsyan, Anna et al. (2017) Coordination of cortical and thalamic activity during non-REM sleep in humans. Nat Commun 8:15499 |
| Zhang, Shirley L; Bai, Lei; Goel, Namni et al. (2017) Human and rat gut microbiome composition is maintained following sleep restriction. Proc Natl Acad Sci U S A 114:E1564-E1571 |
| Lyons, M Melanie; Keenan, Brendan T; Li, Junxin et al. (2017) Symptomless Multi-Variable Apnea Prediction Index Assesses Obstructive Sleep Apnea Risk and Adverse Outcomes in Elective Surgery. Sleep 40: |
| DeBardeleben, Hilary K; Lopes, Lindsey E; Nessel, Mark P et al. (2017) Stress-Induced Sleep After Exposure to Ultraviolet Light Is Promoted by p53 in Caenorhabditis elegans. Genetics 207:571-582 |
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