This proposal represents the second competing renewal of our Training Grant. During the last 4 years, our Training Grant has provided 23 trainees the opportunity to develop a strong foundation in lung science, including 14 M.D.s, 2 Ph.D.s and 7 pre-doctoral graduate students. Of the 17 M.D. trainees completing the training program since inception, 10 accepted academic positions, 9 remain in academic positions and 5 have successfully competed for NIH funding. One of the two Ph.D. trainees has a K award pending Council review and the other is still in training. Of the 7 predoctoral students, one is defending her thesis in June 2003 and the others remain in training. There are three major aims of our Training Program: (1) to provide 3 years of rigorous scientific training for physician-scientists enabling them to serve as independent investigators examining scientific questions directly related to human lung disease; (2) to provide up to 3 years of postdoctoral training to Ph.D. scientists focusing their studies in lung biology; (3) to train graduate students from the M.D.-Ph.D. program and four established Ph.D. granting programs - and guide them into careers in lung research. All M.D. trainees will be strongly encouraged to obtain an advanced degree in their field of interest in order to assess trainee commitment and optimize the opportunity for a successful investigative career. Our program features close contact between the trainee and Training Faculty from 4 collegiate units in our Academic Health Center, and the College of Engineering (Institute of Technology). We continue to provide training in 3 major curricular areas: (1) Cell and Molecular Biology; (2) Bioengineering and Integrative Physiology; (3) Clinical Research leading to a Masters in Public Health or Clinical Research. Comprehensive resources and stable research funding in each area provide an outstanding training environment.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007741-13
Application #
7089822
Study Section
Special Emphasis Panel (ZHL1-CSR-G (F1))
Program Officer
Colombini-Hatch, Sandra
Project Start
1994-07-15
Project End
2009-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
13
Fiscal Year
2006
Total Cost
$720,153
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Simones, Ann A; Beisang, Daniel J; Panoskaltsis-Mortari, Angela et al. (2018) Mesenchymal stem cells in the pathogenesis and treatment of bronchopulmonary dysplasia: a clinical review. Pediatr Res 83:308-317
Herrera, Jeremy; Beisang, Daniel J; Peterson, Mark et al. (2018) Dicer1 Deficiency in the Idiopathic Pulmonary Fibrosis Fibroblastic Focus Promotes Fibrosis by Suppressing MicroRNA Biogenesis. Am J Respir Crit Care Med 198:486-496
Sjaastad, Louisa E; Fay, Elizabeth J; Fiege, Jessica K et al. (2018) Distinct antiviral signatures revealed by the magnitude and round of influenza virus replication in vivo. Proc Natl Acad Sci U S A 115:9610-9615
Chesner, Lisa N; Campbell, Colin (2018) A quantitative PCR-based assay reveals that nucleotide excision repair plays a predominant role in the removal of DNA-protein crosslinks from plasmids transfected into mammalian cells. DNA Repair (Amst) 62:18-27
Yang, Libang; Herrera, Jeremy; Gilbertsen, Adam et al. (2018) IL-8 mediates idiopathic pulmonary fibrosis mesenchymal progenitor cell fibrogenicity. Am J Physiol Lung Cell Mol Physiol 314:L127-L136
Chesner, Lisa N; Campbell, Colin (2018) A Simple, Rapid, and Quantitative Assay to Measure Repair of DNA-protein Crosslinks on Plasmids Transfected into Mammalian Cells. J Vis Exp :
Flanders, Scott C; Kim, Janet; Wilson, Samuel et al. (2018) Validating the total illness burden index for prostate cancer (TIBI-CaP) in men with castration-resistant prostate cancer: data from TRUMPET. Future Oncol 14:527-536
Herrera, Jeremy; Henke, Craig A; Bitterman, Peter B (2018) Extracellular matrix as a driver of progressive fibrosis. J Clin Invest 128:45-53
Leehy, Katherine A; Truong, Thu H; Mauro, Laura J et al. (2018) Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models. J Steroid Biochem Mol Biol 176:88-93
Eichorst, John P; Chen, Yan; Mueller, Joachim D et al. (2018) Distinct Pathway of Human T-Cell Leukemia Virus Type 1 Gag Punctum Biogenesis Provides New Insights into Enveloped Virus Assembly. MBio 9:

Showing the most recent 10 out of 114 publications