This application is a competitive renewal for a Multidisciplinary Training Program in Lung Disease. Its goal is to provide training in basic and clinical sciences relevant to the study of pulmonary disease. The program proposes to support 12 postdoctoral fellows (M.D.s and Ph.D.s) per year. The focus of the training program is a two year experience in the laboratory under the close supervision of a faculty trainer, utilizing molecular, cellular, animal modeling, epidemiologic, or clinical approaches. The program utilizes faculty trainers from the Departments of Internal Medicine (Divisions of Pulmonary/Critical Care Medicine and General Medicine), Pediatrics (Hematology/Oncology), Pathology, and Radiology. The program also utilizes faculty trainers form the Departments of Epidemiology and Biostatistics at the University of Michigan School of Public Health. Faculty trainers either have extensive research experience in diverse, but interrelated areas of cellular and molecular biology or in biostatistics, epidemiology, clinical research design or medical economics. All faculty trainers have trained postdoctoral fellows who have subsequently gone on to independent, productive careers in research and teaching. New facilities and faculty have been incorporated into this program to offer outstanding training opportunities in the disciplines of modern biology and the disciplines relevant to rigorous clinical research. The program provides a structured curriculum that contains appropriate course work, exposure to relevant lecture series, and an in depth intensive laboratory and/or clinical research experience. A broad range of research topics is available to trainees, including chemokine biology, the pathobiology of fibrotic lung disease, host defense mechanisms, lymphocyte-macrophage interactions, epithelial cell biology, fibroblast biology, protease biology, arachidonic acid biochemistry, granulocyte biology, pulmonary epidemiology, molecular genetic studies of candidate genes influencing susceptibility to lung disease, outcomes in lung disease, quality improvement, physician decision making, economic assessment of medical interventions, appropriate utilization of medical technology, financing and organization of medical care, medical ethics, and medical education. Continuation of this training grant in lung disease at the University of Michigan will capitalize on the exceptionally strong resources that have been assembled at this institution. The program, as constructed, will produce a cadre of well-trained investigators devoted to understanding the pathogenesis and treatment of pulmonary diseases.
| Viglianti, Elizabeth M; Iwashyna, Theodore J; Winkelman, Tyler N A (2018) Mass Incarceration and Pulmonary Health: Guidance for Clinicians. Ann Am Thorac Soc 15:409-412 |
| Valley, Thomas S; Nallamothu, Brahmajee K; Heung, Michael et al. (2018) Hospital Variation in Renal Replacement Therapy for Sepsis in the United States. Crit Care Med 46:e158-e165 |
| Gurczynski, S J; Zhou, X; Flaherty, M et al. (2018) Bone marrow transplant-induced alterations in Notch signaling promote pathologic Th17 responses to ?-herpesvirus infection. Mucosal Immunol 11:881-893 |
| Costa, Deena Kelly; Valley, Thomas S; Miller, Melissa A et al. (2018) ICU team composition and its association with ABCDE implementation in a quality collaborative. J Crit Care 44:1-6 |
| Salisbury, Margaret L; Gross, Barry H; Chughtai, Aamer et al. (2018) Development and validation of a radiological diagnosis model for hypersensitivity pneumonitis. Eur Respir J 52: |
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| Dickson, Robert P; Erb-Downward, John R; Falkowski, Nicole R et al. (2018) The Lung Microbiota of Healthy Mice Are Highly Variable, Cluster by Environment, and Reflect Variation in Baseline Lung Innate Immunity. Am J Respir Crit Care Med 198:497-508 |
| Bailoor, Kunal; Valley, Thomas; Perumalswami, Chithra et al. (2018) How acceptable is paternalism? A survey-based study of clinician and nonclinician opinions on paternalistic decision making. AJOB Empir Bioeth 9:91-98 |
| Denstaedt, Scott J; Spencer-Segal, Joanna L; Newstead, Michael W et al. (2018) S100A8/A9 Drives Neuroinflammatory Priming and Protects against Anxiety-like Behavior after Sepsis. J Immunol 200:3188-3200 |
| Singer, Benjamin H; Dickson, Robert P; Denstaedt, Scott J et al. (2018) Bacterial Dissemination to the Brain in Sepsis. Am J Respir Crit Care Med 197:747-756 |
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