The objective of this Training Grant application is to generate support for well qualified students to earn a doctoral degree in the area nutrition and cardiovascular disease at the Gerald J. & Dorothy R. Friedman School of Nutrition Science & Policy at Tufts University.
The specific aims of the training program are to: 1) provide trainees with rigorous didactic training in the areas of nutrition, cardiovascular disease, basic sciences and medical ethics; 2) create a supportive environment within which trainees are guided through the process of conducting independent research; 3)develop in each trainee communication skills necessary to effectively disseminate research data in both oral and written form; 4) enable the acquisition to multidisciplinary training to make each trainee competitive upon conclusion of their formal training; 5) instill the skills necessary to become an independent investigator capable of generating research funding; 6) develop a thorough understanding of what constitutes responsible conduct of research; and 7) secure a postdoctoral position on completion of the program. The Program Faculty is drawn from a broad range of disciplines; each member currently directs a vibrant research program and has an extensive history of inter-investigator collaboration. They contribute expertise in the areas of lipids and lipoproteins, genetics, folate/homocysteine (epidemiology and basic science), obesity, cardiovascular disease risk factors and mechanisms, vitamin K, immunology, vascular biology, nutrition assessment, cardiac function and oxidative stress, and atherosclerotic plaque stability. This environment is supplemented by the combined resources of the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Tufts University School of Medicine, and the Sackler School of Graduate Biomedical Sciences that together provide a fertile environment in which predoctoral students can fulfill the aforementioned aims. The symposia, seminars and meetings of institutions in the greater Boston area further serve to supplement these resources.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL069772-03
Application #
6910703
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Scott, Jane
Project Start
2003-07-01
Project End
2008-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
3
Fiscal Year
2005
Total Cost
$160,497
Indirect Cost
Name
Tufts University
Department
Type
Organized Research Units
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
Hannou, Sarah A; Haslam, Danielle E; McKeown, Nicola M et al. (2018) Fructose metabolism and metabolic disease. J Clin Invest 128:545-555
Meng, Huicui; Matthan, Nirupa R; Fried, Susan K et al. (2018) Effect of Dietary Carbohydrate Type on Serum Cardiometabolic Risk Indicators and Adipose Tissue Inflammatory Markers. J Clin Endocrinol Metab 103:3430-3438
Roe, Annie J; Zhang, Shucha; Bhadelia, Rafeeque A et al. (2017) Choline and its metabolites are differently associated with cardiometabolic risk factors, history of cardiovascular disease, and MRI-documented cerebrovascular disease in older adults. Am J Clin Nutr 105:1283-1290
Haslam, Danielle E; McKeown, Nicola M; Herman, Mark A et al. (2017) Interactions between Genetics and Sugar-Sweetened Beverage Consumption on Health Outcomes: A Review of Gene-Diet Interaction Studies. Front Endocrinol (Lausanne) 8:368
Pojednic, Rachele M; Ceglia, Lisa; Lichtenstein, Alice H et al. (2015) Vitamin D receptor protein is associated with interleukin-6 in human skeletal muscle. Endocrine 49:512-20
Pojednic, Rachele M; Ceglia, Lisa; Olsson, Karl et al. (2015) Effects of 1,25-dihydroxyvitamin D3 and vitamin D3 on the expression of the vitamin d receptor in human skeletal muscle cells. Calcif Tissue Int 96:256-63
Ip, Blanche C; Liu, Chun; Lichtenstein, Alice H et al. (2015) Lycopene and apo-10'-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in ?-carotene-9',10'-oxygenase knockout male mice. J Nutr 145:268-76
Honda, Kaori L; Lamon-Fava, Stefania; Matthan, Nirupa R et al. (2015) Docosahexaenoic acid differentially affects TNF? and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages. Prostaglandins Leukot Essent Fatty Acids 97:27-34
Honda, Kaori L; Lamon-Fava, Stefania; Matthan, Nirupa R et al. (2015) EPA and DHA exposure alters the inflammatory response but not the surface expression of Toll-like receptor 4 in macrophages. Lipids 50:121-9
Bennett, Grace; Strissel, Katherine J; DeFuria, Jason et al. (2014) Deletion of TNF-like weak inducer of apoptosis (TWEAK) protects mice from adipose and systemic impacts of severe obesity. Obesity (Silver Spring) 22:1485-94

Showing the most recent 10 out of 76 publications