We seek to renew funding for this successful physician-scientist training program that was first awarded in January 2007. The goal of our program is to develop two integrated but separate pathways that provide integrated scientific training in clinical trials, epidemiology, comparative effectiveness, and outcomes research and in translational approaches in cellular and animal models of inflammation. In this renewal, we propose to include faculty mentors from the Department of Pediatrics and post- doctoral trainees who will focus on pediatric and neonatal lung diseases. The fundamental component of our program has been to develop a strong mentorship platform to support successful academic careers for physician-scientists; one that employs an intensive and diverse approach to formal scientific training for candidates who have completed or will complete clinical training in adult pulmonary medicine, critical care medicine, or neonatology and who have a strong commitment to an academic career.
We aim to train highly select individuals in a scientific body of knowledge that is related to the primary and secondary role of inflammation and innate immunity in a wide spectrum of lung and pulmonary vascular diseases. We believe that this scientific platform pertains broadly to the widest variety of lung diseases that share a prominent inflammatory feature and include the very prevalent diseases of asthma and COPD, interstitial lung disease, occupational and environmental lung disease, acute respiratory distress syndrome, chronic lung disease of infancy and pulmonary hypertension in the newborn. We hypothesize that an integrated program that is focused on both clinical and basic research in the context of both pediatric and adult lung diseases will inspire a new generation of successful physician-scientists. All trainees will develop an individualized research program, learn to write grant proposals, and receive career counseling and assistance in academic job placement. The progress of the trainees and their mentors will be closely monitored by a research advisory committee, internal executive committee, external advisory board, and the principal investigator. Our program is designed to emphasize novel molecular approaches in an ethical and scientifically responsible environment and has a strong commitment to attracting individuals from under-represented minorities.

Public Health Relevance

Lay Description: We aim to develop a strong mentorship platform to support an intensive and diverse approach to formal scientific training for candidates who have completed or will complete clinical training in adult pulmonary medicine, critical care medicine, or neonatology and who have a strong commitment to an academic career. We hypothesize that an integrated program that is focused on both clinical and basic research in the context of both pediatric and adult lung diseases will inspire a new generation of successful physician-scientists. Our program is designed to emphasize novel molecular approaches in an ethical and scientifically responsible environment and has a strong commitment to attracting individuals from under-represented minorities.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL082547-09
Application #
8838849
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Colombini-Hatch, Sandra
Project Start
2006-05-01
Project End
2017-04-30
Budget Start
2015-05-01
Budget End
2016-04-30
Support Year
9
Fiscal Year
2015
Total Cost
$317,614
Indirect Cost
$25,564
Name
University of Illinois at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Ayee, Manuela Aseye Ayele; LeMaster, Elizabeth; Teng, Tao et al. (2018) Hypotonic Challenge of Endothelial Cells Increases Membrane Stiffness with No Effect on Tether Force. Biophys J 114:929-938
Karpurapu, Manjula; Lee, Yong Gyu; Qian, Ziqing et al. (2018) Inhibition of nuclear factor of activated T cells (NFAT) c3 activation attenuates acute lung injury and pulmonary edema in murine models of sepsis. Oncotarget 9:10606-10620
Shamaei, Masoud; Mirsaeidi, Mehdi; Baghaei, Parvaneh et al. (2017) Recurrent Drug-Induced Hepatitis in Tuberculosis-Comparison of Two Drug Regimens. Am J Ther 24:e144-e149
Zaidi, Farhan; Lee, Ryan S; Buchcic, Bartosz A et al. (2017) Evaluation and Documentation of Supplemental Oxygen Requirements is Rarely Performed in Patients Hospitalized With COPD. Chronic Obstr Pulm Dis 4:287-296
Ascoli, Christian; Huang, Yue; Schott, Cody et al. (2017) A Circulating Micro-RNA Signature Serves as a Diagnostic and Prognostic Indicator in Sarcoidosis. Am J Respir Cell Mol Biol :
Ayee, Manuela A A; LeMaster, Elizabeth; Shentu, Tzu Pin et al. (2017) Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids. Biophys J 112:325-338
Qian, Feng; Deng, Jing; Wang, Gang et al. (2016) Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases. Curr Protein Pept Sci 17:332-42
Fraidenburg, Dustin R; Machado, Roberto F (2016) Pulmonary hypertension associated with thalassemia syndromes. Ann N Y Acad Sci 1368:127-39
Prieto-Centurion, Valentin; Bracken, Nina; Norwick, Lourdes et al. (2016) Can Commercially Available Pedometers Be Used For Physical Activity Monitoring In Patients With COPD Following Exacerbations? Chronic Obstr Pulm Dis 3:636-642
Omar, Hesham R; Mirsaeidi, Mehdi; Shumac, Jacob et al. (2016) Incidence and predictors of ischemic cerebrovascular stroke among patients on extracorporeal membrane oxygenation support. J Crit Care 32:48-51

Showing the most recent 10 out of 65 publications