The purpose of this program, which is entering its 36th year, is to train postdoctoral fellows in research on a variety of types of plasticity that influence the nervous system, including neuronal development, changes in motivational state, selective attention, learning, and disease. The neurobiological bases of these processes will be studied, emphasizing analyses of synaptic specification, control of gene expression, structure of the cytoskeleton, synaptic plasticity, organization of neural circuits, structure and gating properties of membrane conductance channels, neurochemistry of synaptic transmission, axonal transport and neuronal regeneration. A multidisciplinary approach will be taught that in most cases can be directed towards an analysis of these problems at the molecular level. Training will be offered in a variety of disciplines, including membrane biophysics, anatomy and cell biology, behavior, development, electrophysiology, molecular biology, neurochemistry, pharmacology and physiology, and brain imaging. Each fellow will be encouraged to become familiar with a variety of neurobiological disciplines in order to instill a problem-oriented, as opposed to a technique-oriented, approach to science. Trainees will be encouraged to work on problems of fundamental importance to basic neural science, with the long term goal that the resulting knowledge will someday be of importance in the prevention and treatment of neurological and psychiatric diseases. The training faculty are members of the Center for Neurobiology or (in one case) the Department of Psychiatry of Columbia University. The training program is built primarily around the research and training activities and the facilities of the Center. The 29 members of the training faculty have a wide diversity of expertise, and various members hold joint appointments in 7 different basic science and clinical departments of the University. There will be extensive active collaboration between members of the training faculty in their research and in the training of pre- and postdoctoral students. Trainees will participate in graduate courses and seminars, but their primary training experience will come in an intensive 3-4 year research program in the laboratory of one of the training faculty. The program will be broadly advertised at the national level, and a vigorous effort will be made to recruit women and members of underrepresented minority groups. Funds are requested for four postdoctoral trainees per year.
| Miranda, André M; Lasiecka, Zofia M; Xu, Yimeng et al. (2018) Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures. Nat Commun 9:291 |
| Jimenez, Jessica C; Su, Katy; Goldberg, Alexander R et al. (2018) Anxiety Cells in a Hippocampal-Hypothalamic Circuit. Neuron 97:670-683.e6 |
| Hong, Y Kate; Lacefield, Clay O; Rodgers, Chris C et al. (2018) Sensation, movement and learning in the absence of barrel cortex. Nature 561:542-546 |
| Semework, Mulugeta; Steenrod, Sara C; Goldberg, Michael E (2018) A spatial memory signal shows that the parietal cortex has access to a craniotopic representation of space. Elife 7: |
| Foley, Nicholas C; Kelly, Simon P; Mhatre, Himanshu et al. (2017) Parietal neurons encode expected gains in instrumental information. Proc Natl Acad Sci U S A 114:E3315-E3323 |
| McGowan, Josephine C; LaGamma, Christina T; Lim, Sean C et al. (2017) Prophylactic Ketamine Attenuates Learned Fear. Neuropsychopharmacology 42:1577-1589 |
| Patel, Tulsi; Hobert, Oliver (2017) Coordinated control of terminal differentiation and restriction of cellular plasticity. Elife 6: |
| Perusini, Jennifer N; Cajigas, Stephanie A; Cohensedgh, Omid et al. (2017) Optogenetic stimulation of dentate gyrus engrams restores memory in Alzheimer's disease mice. Hippocampus 27:1110-1122 |
| Sundaram, Vasavi; Choudhary, Mayank N K; Pehrsson, Erica et al. (2017) Functional cis-regulatory modules encoded by mouse-specific endogenous retrovirus. Nat Commun 8:14550 |
| Nautiyal, Katherine M; Okuda, Mayumi; Hen, Rene et al. (2017) Gambling disorder: an integrative review of animal and human studies. Ann N Y Acad Sci 1394:106-127 |
Showing the most recent 10 out of 91 publications
