The epidemics of delinquency, violence, school drop-out, and drug abuse have been studied in regard to antecedent risk behaviors and conditions. Specific early risk factors are now being targeted by prevention programs in randomized field trials. In recent years an important structure for prevention science has emerged based on progress in research on early risk and protective factors along developmental paths as early as first grade and possibly earlier. These have been designated targets for preventive intervention trials here in Baltimore and elsewhere (Durlak &Wells, 1997;Gersten, Seals &Kallgren, 1991;Kellam &Van Horn, 1997). This prevention research strategy is based on an integration of three scientific perspectives: The first is life course development with a focus on early risk and protective factors and developmental paths;the second is community epidemiology with a focus on defined populations in their environment, variation in developmental paths, and control of selection bias;and the third is experimental interventions precisely targeting early risk factors in developmental models (Mrazek &Haggerty, 1994;NIMH, 1993;Kellam &Rebok, 1992). This form of prevention science is multi-disciplinary, requiring the coming together of biological, psychiatric, psychological, social and cultural, economic, and biostatistical disciplines. The numbers of researchers is severely limited, and the need for training the next generation of prevention researchers is very high priority (Mrazek &Haggerty, 1994;NIMH, 1993). This application is for a five year continuation of the Johns Hopkins Prevention Research Training Program, that grew out of the Johns Hopkins Prevention Research Intervention Center and its first two generations of preventive trials. Candidates will continue to be recruited from disciplines including psychology, psychiatry, sociology, biology, biostatistics, and economics. Prevention research training will continue to be centered on developmental modeling, design of epidemiologically based randomized field trials, biostatistical methodology, and designing partnerships with community and institutions for randomized field trials. More intensive training will be done during this next five years on the neuropsychological and genetic underpinnings of behavior, the role of community factors in development and psychopathology and as moderators of intervention response, and economic analyses of preventive interventions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH018834-24
Application #
8082751
Study Section
Special Emphasis Panel (ZMH1-ERB-I (01))
Program Officer
Hill, Lauren D
Project Start
1988-08-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
24
Fiscal Year
2011
Total Cost
$220,479
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Musci, Rashelle J; Fairman, Brian; Masyn, Katherine E et al. (2018) Polygenic Score × Intervention Moderation: an Application of Discrete-Time Survival Analysis to Model the Timing of First Marijuana Use Among Urban Youth. Prev Sci 19:6-14
Domitrovich, Celene E; Bradshaw, Catherine P; Berg, Juliette K et al. (2016) How Do School-Based Prevention Programs Impact Teachers? Findings from a Randomized Trial of an Integrated Classroom Management and Social-Emotional Program. Prev Sci 17:325-37
Lash, Denise N; Smith, Jane Ellen; Rinehart, Jenny K (2016) Can the Theory of Planned Behavior predict dietary intention and future dieting in an ethnically diverse sample of overweight and obese veterans attending medical clinics? Appetite 99:185-192
Musci, Rashelle J; Masyn, Katherine E; Benke, Kelly et al. (2016) The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence. Dev Psychopathol 28:225-37
Newcomer, Alison R; Roth, Kimberly B; Kellam, Sheppard G et al. (2016) Higher Childhood Peer Reports of Social Preference Mediates the Impact of the Good Behavior Game on Suicide Attempt. Prev Sci 17:145-56
Rinehart, Jenny K; Yeater, Elizabeth A (2015) Using cognitive theory and methodology to inform the study of sexual victimization. Trauma Violence Abuse 16:3-15
Musci, Rashelle J; Masyn, Katherine E; Uhl, George et al. (2015) Polygenic score × intervention moderation: an application of discrete-time survival analysis to modeling the timing of first tobacco use among urban youth. Dev Psychopathol 27:111-22
Musci, Rashelle J; Uhl, George; Maher, Brion et al. (2015) Testing gene × environment moderation of tobacco and marijuana use trajectories in adolescence and young adulthood. J Consult Clin Psychol 83:866-74
Lee, Grace P; Stuart, Elizabeth A; Ialongo, Nicholas S et al. (2014) Parental monitoring trajectories and gambling among a longitudinal cohort of urban youth. Addiction 109:977-85
Musci, Rashelle J; Bradshaw, Catherine P; Maher, Brion et al. (2014) Reducing aggression and impulsivity through school-based prevention programs: a gene by intervention interaction. Prev Sci 15:831-40

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