The overall purpose of this training program is to increase the number of researchers is the area of schizophrenia who have the ability to apply modern techniques of clinical research and incorporate recent developments is neuroscience into their investigations. Training in the disciplines of psychopharmacology, brain imaging, genetics, neuropathology, neuropsychology, molecular neurobiology and epidemiology will be offered by participating faculty actively engaged is schizophrenia-related research. All members have federally-funded research projects. The training will develop research skills by supervised participation is ongoing research, but the trainee will be expected to construct and execute independent projects as well. Didactic work focuses on research design and statistics, and a weekly schizophrenia research seminar reviews current schizophrenia research in all areas. Trainees for the project will primarily be psychiatrists who have completed both their medical school training and 4 years of residency. These trainees have had considerable experience with the diagnosis and treatment of major psychiatric disorders, including schizophrenia, but are likely to lack specific research skills such as developing testable hypotheses, designing a feasible research study acceptable to institutional review boards, and the collection and analysis of standardized research data. In addition to these MD psychiatrists, we expect that we will recruit MD/PhD psychiatrists with a background in basic science research. PhD psychologists, MD neurologists, and PhD biologists with a special interest in schizophrenia. We will adapt the training to suit their background and interests. Eight stipends are requested to support 2 to 3 fellows per year, with most projected to receive some support for a third year of training. This program will be conducted at the New York State Psychiatric Institute (NYSPI), the Creedmoor Psychiatric Center (CPC) in Queens, NY, and the Columbia-Presbyterian campus of the New York Presbyterian Hospital (NYPH), by faculty members of Columbia University at these institutions. With a total of over fifty million dollars annually is federal grants, a research institute with 64 beds (including a 12 bed designated schizophrenia inpatient research unit funded by NYS at NYSPI), another 25 research beds at CPC similarly funded, an NIMH schizophrenia center grant, a Hughes Institute, and 5 other MHCRCs, there exists the research personnel and clinical facilities to continue to execute this proposed training program, which has had excellent success is its training efforts thus far.
| Harris, Alexander Z; Atsak, Piray; Bretton, Zachary H et al. (2018) A Novel Method for Chronic Social Defeat Stress in Female Mice. Neuropsychopharmacology 43:1276-1283 |
| Avissar, Michael; Xie, Shanghong; Vail, Blair et al. (2018) Meta-analysis of mismatch negativity to simple versus complex deviants in schizophrenia. Schizophr Res 191:25-34 |
| Abbas, Atheir I; Sundiang, Marina J M; Henoch, Britt et al. (2018) Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding. Neuron 100:926-939.e3 |
| Maxwell, Seth D; Fineberg, Anna M; Drabick, Deborah A et al. (2018) Maternal Prenatal Stress and Other Developmental Risk Factors for Adolescent Depression: Spotlight on Sex Differences. J Abnorm Child Psychol 46:381-397 |
| Weinstein, J J; van de Giessen, E; Rosengard, R J et al. (2018) PET imaging of dopamine-D2 receptor internalization in schizophrenia. Mol Psychiatry 23:1506-1511 |
| Lovejoy, Lee P; Krauzlis, Richard J (2017) Changes in perceptual sensitivity related to spatial cues depends on subcortical activity. Proc Natl Acad Sci U S A 114:6122-6126 |
| Samuels, Benjamin Adam; Nautiyal, Katherine M; Kruegel, Andrew C et al. (2017) The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor. Neuropsychopharmacology 42:2052-2063 |
| Bolkan, Scott S; Stujenske, Joseph M; Parnaudeau, Sebastien et al. (2017) Thalamic projections sustain prefrontal activity during working memory maintenance. Nat Neurosci 20:987-996 |
| Dubin, Marc J; Liston, Conor; Avissar, Michael A et al. (2017) Network-Guided Transcranial Magnetic Stimulation for Depression. Curr Behav Neurosci Rep 4:70-77 |
| van de Giessen, E; Weinstein, J J; Cassidy, C M et al. (2017) Deficits in striatal dopamine release in cannabis dependence. Mol Psychiatry 22:68-75 |
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