This application is for a 5-year renewal of the T32 Training Program in the Development of Psychopathology: From Brain and Behavior to Intervention. Mental and substance abuse disorders are more likely to arise early in life...[and] are, in fact, the predominant noncommunicable disorders of young people (Insel, 2014; p. 1727). Therefore, early identification of risk processes and early intervention are crucial. As the field has been shifting from a behavioral to a neurodevelopmental focus, this training program also has been evolving to reflect important advances in human brain development. The major thrust of this interdisciplinary program is to produce scientists who will (1) contribute to the state of knowledge about neurobiological and psychosocial mechanisms underlying the development and maintenance of psychopathology, and (2) translate findings from basic research to the development of empirically-based interventions for the prevention and amelioration of psychopathology and for the promotion of mental health. The training program provides individual mentoring in multidisciplinary science complemented by didactic activities. A personalized training plan is developed for each fellow and re-evaluated each semester. In the last five years, we have explicitly shifted our focus to increasing training on multidisciplinary research on neurobiological, psychophysiological, genetic, and psychosocial mechanisms underlying psychiatric illness. Since the last renewal in 2010, three of the 11 (27%) predoctoral trainees and two of the five postdocs (40%) have come from neuroscience programs. In the last decade, over 75% of our 24 pre- and 12 post-doctoral trainees have continued to contribute to the field through scholarly research and teaching. A quarter of trainees represent diverse ethnic minority groups and 67% have been female. Four predocs continue in training on this T32; 3 other former predoc trainees are working on their dissertations; 3 are doing their required clinical internship. All 14 remaining former predoc trainees have completed their PhDs; 6 are researchers in faculty positions in academic psychology departments; 2 are postdoctoral fellows; 4 do a combination of clinical service, consulting, teaching, and supervision, and 2 are doing clinical work. Of the 12 postdoctoral fellows, 3 continue in training; 7 of the 9 former postdocs are still actively involved in research and teaching. Other important indicators of the training program's success are trainees' publication records [predocs: 141 papers, mean=5.9; median=5; postdocs: 157 papers, mean=13.08; median =13] and their acquisition of research funding from individual career development awards (F30, F31, K01, K99), R-type grants (e.g., R34, R21, R00), and foundations (e.g., Brain Behavior Research Fund). This renewal application proposes to again support 4 predoctoral trainees and 3 postdoctoral fellows annually. Our primary goals for the next five years are to continue to develop research scientists who can discover and translate basic knowledge from clinical neuroscience into interventions for reducing psychopathology. We will especially focus on the Research Domain Criteria (RDoC), grant writing, and professional development.

Public Health Relevance

The primary aim of this interdisciplinary training program is to produce scientists who will (a) discover neurobiological and psychosocial mechanisms underlying the development and maintenance of psychopathology, and (b) translate this basic knowledge into empirically-based interventions that reduce current and future psychopathology and promote mental health and adaptation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH018921-29
Application #
9523152
Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Sarampote, Christopher S
Project Start
1989-07-01
Project End
2020-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
29
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Psychiatry
Type
Schools of Medicine
DUNS #
965717143
City
Nashville
State
TN
Country
United States
Zip Code
37240
Hinton, Kendra E; Lahey, Benjamin B; Villalta-Gil, Victoria et al. (2018) Right Fronto-Subcortical White Matter Microstructure Predicts Cognitive Control Ability on the Go/No-go Task in a Community Sample. Front Hum Neurosci 12:127
Brunwasser, Steven M; Freres, Derek R; Gillham, Jane E (2018) Youth Cognitive-Behavioral Depression Prevention: Testing Theory in a Randomized Controlled Trial. Cognit Ther Res 42:468-482
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Arditte Hall, Kimberly A; Quinn, Meghan E; Vanderlind, William M et al. (2018) Comparing cognitive styles in social anxiety and major depressive disorders: An examination of rumination, worry, and reappraisal. Br J Clin Psychol :
Brunwasser, Steven M; Gebretsadik, Tebeb; Gold, Diane R et al. (2018) A new model of wheezing severity in young children using the validated ISAAC wheezing module: A latent variable approach with validation in independent cohorts. PLoS One 13:e0194739
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Porter, Andrew C; Zelkowitz, Rachel L; Cole, David A (2018) The unique associations of self-criticism and shame-proneness to symptoms of disordered eating and depression. Eat Behav 29:64-67
Sutherland, Susanna; Brunwasser, Steven M (2018) Sex Differences in Vulnerability to Prenatal Stress: a Review of the Recent Literature. Curr Psychiatry Rep 20:102
Zelkowitz, Rachel L; Cole, David A (2018) Self-Criticism as a Transdiagnostic Process in Nonsuicidal Self-Injury and Disordered Eating: Systematic Review and Meta-Analysis. Suicide Life Threat Behav :
Brunwasser, Steven M; Gillham, Jane E (2018) Identifying Moderators of Response to the Penn Resiliency Program: A Synthesis Study. Prev Sci 19:38-48

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