Abstract

The aim of this competing continuation application for an interdisciplinary training program in HIV (HIV-1 infection and AIDS) is to provide state of the art research training for 5 postdoctoral fellows (MD. MD/Ph.D., DO, or Ph.D.) and 2 predoctoral fellows. The program is designed to develop independent researchers in medical and basic science disciplines which address neuro- and psycho-biology of HIV infection. Trainees will be provided with 1) a comprehensive introduction to a wide variety of disciplines, ranging from epidemiology of HIV infection, through psychosocial factors affecting disease progression, to neurobiology of HIV and consequent immune responses; and 2) an in-depth basic and/or clinical research experience in one focused aspect of HIV. Trainees will spend approximately 90% of their time in research, while broadening and deepening their knowledge by participating in a core seminar and taking selected classes. Each trainee will be required to produce a 3 to 5 page grant application during the first year of the program and a first-authored paper during the second year of the program. Each trainee's curriculum is individually designed to meet their needs and the hands-on research experience is tailored to provide experiences needed to develop independent researchers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH019200-14
Application #
6538468
Study Section
Special Emphasis Panel (ZMH1-BRB-T (07))
Program Officer
Chavez, Mark
Project Start
1989-09-30
Project End
2004-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
14
Fiscal Year
2002
Total Cost
$138,865
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Youssef, A Samy; Guiot, Bernard; Black, Keith et al. (2008) Modifications of the transoral approach to the craniovertebral junction: anatomic study and clinical correlations. Neurosurgery 62:145-54;discussion 154-5
Newton, T F; Leuchter, A F; van Gorp, W G et al. (1997) EEG power correlates with subcortical metabolic activity in AIDS. J Neuropsychiatry Clin Neurosci 9:574-8
Koka, P; He, K; Zack, J A et al. (1995) Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor alpha, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain. J Exp Med 182:941-51
Koka, P; He, K; Camerini, D et al. (1995) The mapping of HIV-1 gp160 epitopes required for interleukin-1 and tumor necrosis factor alpha production in glial cells. J Neuroimmunol 57:179-91
Liu, M; Fahey, J L; Aziz, N et al. (1994) Zidovudine and dideoxycytidine differ in their effects on human immunodeficiency virus-induced pathologic activation of the immune system. AIDS Clinical Trial Research Group 047. J Infect Dis 170:1165-71
von Einsiedel, R W; Fife, T D; Aksamit, A J et al. (1993) Progressive multifocal leukoencephalopathy in AIDS: a clinicopathologic study and review of the literature. J Neurol 240:391-406
Zhong, L T; Kane, D J; Bredesen, D E (1993) BCL-2 blocks glutamate toxicity in neural cell lines. Brain Res Mol Brain Res 19:353-5
Cornford, M E; Ho, H W; Vinters, H V (1992) Correlation of neuromuscular pathology in acquired immune deficiency syndrome patients with cytomegalovirus infection and zidovudine treatment. Acta Neuropathol 84:516-29
Cornford, M E; Holden, J K; Boyd, M C et al. (1992) Neuropathology of the acquired immune deficiency syndrome (AIDS): report of 39 autopsies from Vancouver, British Columbia. Can J Neurol Sci 19:442-52
Cornford, M E; Said, J W; Vinters, H V (1991) Immunohistochemical localization of human immunodeficiency virus (HIV) in central nervous system lymphoproliferative disorders of patients with AIDS. Mod Pathol 4:232-8

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