Abstract

This is a resubmission of a competing renewal application for funding to support a postdoctoral training program aimed at producing clinical researchers who are qualified to be independent investigators studying PTSD and related consequences of traumatic stress. The application proposes to train four postdoctoral fellows during each year of the five year award, with a total of 8 fellows completing the two year fellowship program and 4 fellows completing one year of the program during the proposed award period. The training program is housed within VA Boston Healthcare System and is affiliated with Boston University School of Medicine. The program is designed to provide training in five core domains relevant to the next generation of investigators who study topics related to traumatic stress. These domains include a) neuroimaging and clinical neuroscience; b) molecular biomarkers and genetics; c) assessment, diagnosis, and epidemiology; d) treatment development and optimization; and e) implementation and dissemination. Core faculty have established programs of research, are highly productive, are active collaborators across domains of expertise, and have an extensive record of successful mentorship. Support faculty include junior investigators who serve in an apprentice role as supervisors and mentors. Faculty affiliations with other programs at both primary institutions afford additional training and research opportunities. The training program continues its commitment to recruit diverse candidates and to provide training in research with diverse populations. The application provides detailed information on the proposed training program and the success of the training program to date.

Public Health Relevance

Posttraumatic stress disorder (PTSD) is a prevalent, chronic, and disabling condition. The goal of the proposed training program is to provide advanced training and professional development experiences to postdoctoral fellows who will comprise the next generation of expert investigators in this important public health area.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
3T32MH019836-16A1S1
Application #
9412294
Study Section
Special Emphasis Panel (ZMH1-ERB-M (01))
Program Officer
Chavez, Mark
Project Start
2016-12-01
Project End
2017-06-30
Budget Start
2016-12-01
Budget End
2017-06-30
Support Year
16
Fiscal Year
2017
Total Cost
$4,778
Indirect Cost
$354

  Institution

Name
Boston University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Thompson-Hollands, Johanna; Marx, Brian P; Lee, Daniel J et al. (2018) Long-term treatment gains of a brief exposure-based treatment for PTSD. Depress Anxiety 35:985-991
McCullough, Kenneth M; Morrison, Filomene G; Hartmann, Jakob et al. (2018) Quantified Coexpression Analysis of Central Amygdala Subpopulations. eNeuro 5:
Sullivan, Danielle R (2018) A Cerebrovascular Hypothesis of Neurodegeneration in mTBI. J Head Trauma Rehabil :
Dutra, Sunny J; Sadeh, Naomi (2018) Psychological flexibility mitigates effects of PTSD symptoms and negative urgency on aggressive behavior in trauma-exposed veterans. Personal Disord 9:315-323
Wolf, Erika J; Miller, Mark W; Sullivan, Danielle R et al. (2018) A classical twin study of PTSD symptoms and resilience: Evidence for a single spectrum of vulnerability to traumatic stress. Depress Anxiety 35:132-139
Wolf, Erika J; Logue, Mark W; Morrison, Filomene G et al. (2018) Posttraumatic psychopathology and the pace of the epigenetic clock: a longitudinal investigation. Psychol Med :1-10
Sloan, Denise M; Unger, William; Lee, Daniel J et al. (2018) A Randomized Controlled Trial of Group Cognitive Behavioral Treatment for Veterans Diagnosed With Chronic Posttraumatic Stress Disorder. J Trauma Stress 31:886-898
Morrison, Filomene G; Miller, Mark W; Wolf, Erika J et al. (2018) Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression. Neurosci Lett 692:204-209
Hayes, J P; Reagan, A; Logue, M W et al. (2018) BDNF genotype is associated with hippocampal volume in mild traumatic brain injury. Genes Brain Behav 17:107-117
Miller, Danielle R; Logue, Mark W; Wolf, Erika J et al. (2017) Posttraumatic stress disorder symptom severity is associated with reduced default mode network connectivity in individuals with elevated genetic risk for psychopathology. Depress Anxiety 34:632-640

Showing the most recent 10 out of 46 publications