We shall seek out, nurture, and train honors students in STEM majors related to biomedical disciplines of Biology, Chemistry, Physics and Mathematics for entry into strong graduate programs with the ultimate goal of graduation with a Ph.D. degree in their chosen field. The program will be research intensive, each student working in a group with our finest research faculty for a period of up to 24 months with the experience culminating in the mandatory writing and oral defense of a research Thesis. The student will be expected to attend scientific meeting, initially as an observer to familiarize themselves with the culture and design of such meetings, and later to present their research results to the chosen scientific community. Along with the research exposure and training the students will have special focused classes on Bioethics and Responsible Conduct of Research. The Bioethics course will be taught by faculty from the Department of Philosophy and will be a specific course focused on the MARC students, intense and intellectually broad as befits students with aspirations of the Ph. D. degree and later research- oriented careers. The Responsible Conduct of Research will be part of a weekly ?Introduction to Research:' course and will be directed by the PD, as a more hands-on day to day inquiry into the pitfalls open to the research community. It will include examples of the ?crime? and the ?punishment? as evidenced from the NIH Office of Research Integrity and the related NSF office. The ?Introduction to Research? class will also involve a series of ?Conversations with Scholars? where our top University Scholars come for informal sessions to describe their work, and their personal stories en route from student to faculty, and the hurdles faced and overcome. The students will be encouraged to participate in a summer research experience off-campus in the knowledge that many of our students have little or no experience outside our somewhat isolated region, and the received understanding that their ?home? laboratory and training and personal talent makes them competitive for graduate school is often of great importance to their development. Such experiences can be special programs organized by many Universities for this student audience; National Laboratory Programs, e.g. DOE, DOD, or special arrangement made by the research director. Finally we have designed two classes ?Bioinformatics? and ?Entrepreneurship in Science? as two key experiences to enhance their training and career ideas/options.

Public Health Relevance

This proposal seeks out, trains, and mentors outstanding underrepresented students for careers in the biomedically related Sciences. The program is focused upon an intensive 24 month (junior and senior) UG research experience, culminating in an oral defense a Thesis. Special courses in ethics (philosophy), the responsible conduct of research, bioinformatics and science-entrepreneurship are included as is a summer off-campus research experience. The goal of the program is to have all graduates from the program enter graduate school and progress on to earning a Ph.D. for subsequent entry into biomedical research-oriented careers, academic, industrial or National laboratories/ classrooms, thereby increasing the manpower in the USA for finding new approaches to curing disease and general betterment of the Health of the Nation.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
MARC Undergraduate NRSA Institutional Grants (T34)
Project #
3T34GM008048-35S1
Application #
10127397
Study Section
Program Officer
Brown, Patrick
Project Start
2020-06-01
Project End
2021-05-31
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
35
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Texas El Paso
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
132051285
City
El Paso
State
TX
Country
United States
Zip Code
79968
Castillo, Maximiliano; Barreda, Omar; Maity, Arnab K et al. (2016) Advances in Guanidine Ligand Design: Synthesis of a Strongly Electron-Donating, Imidazolin-2-iminato Functionalized Guanidinate and its Properties on Iron. J Coord Chem 69:2003-2014
Robles-Escajeda, Elisa; Das, Umashankar; Ortega, Nora M et al. (2016) A novel curcumin-like dienone induces apoptosis in triple-negative breast cancer cells. Cell Oncol (Dordr) 39:265-77
Torres, Oscar V; Walker, Ellen M; Beas, Blanca S et al. (2014) Female rats display enhanced rewarding effects of ethanol that are hormone dependent. Alcohol Clin Exp Res 38:108-15
Nunes, Larissa M; Robles-Escajeda, Elisa; Santiago-Vazquez, Yahaira et al. (2014) The gender of cell lines matters when screening for novel anti-cancer drugs. AAPS J 16:872-4
Ashmus, Roger A; Schocker, Nathaniel S; Cordero-Mendoza, Yanira et al. (2013) Potential use of synthetic ?-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease. Org Biomol Chem 11:5579-83
Li, Xiujun James; Valadez, Alejandra V; Zuo, Peng et al. (2012) Microfluidic 3D cell culture: potential application for tissue-based bioassays. Bioanalysis 4:1509-25
Varela-Ramirez, Armando; Costanzo, Margaret; Carrasco, Yazmin P et al. (2011) Cytotoxic effects of two organotin compounds and their mode of inflicting cell death on four mammalian cancer cells. Cell Biol Toxicol 27:159-68
Tolonen, Ellen; Bueno, Brenda; Kulshreshta, Sanjeev et al. (2011) Allosteric transition and binding of small molecule effectors causes curvature change in central ?-sheets of selected enzymes. J Mol Model 17:899-911
Pal, Sangita; Santos, Andres; Rosas, Juan M et al. (2011) Influenza A virus interacts extensively with the cellular SUMOylation system during infection. Virus Res 158:12-27
Vargas-Pineda, Diana Gabriela; Guardado, Tanya; Cervantes-Lee, Francisco et al. (2010) Intramolecular chalcogen-tin interactions in [(o-MeEC6H4)CH2]2SnPh(2-n)Cl(n) (E = S, O, CH2; n = 0, 1, 2) and intermolecular chlorine-tin interactions in the meta- and para-methoxy isomers. Inorg Chem 49:960-8

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