This application requests continued support for an interdepartmental training program in Infectious Diseases and Inflammatory Disorders. It is designed to foster the interests of outstanding medical students in biomedical research. During the current funding period (2009-2013), this program has offered training opportunities for a total of 32 trainees, leading to publication/submission of 10 peer-reviewed manuscripts and 14 poster awards at national/regional scientific meetings. Importantly, this enrichment program combines the faculty's innovative research expertise with unique institutional strengths for the education o medical students. Hands-on training will be provided by 18 faculty members from six basic science and clinical departments at UTMB. The research themes will be centered on infections and inflammation, especially on transmission of pathogens, regulation of host inflammatory responses at the sites of pathogen entry (airway, skin, and mucosa), regulation of leukocyte migration in the blood, liver and other organs, and vaccine/drug development for the control of pathogens and tissue damage. Trainees (9 per year, 45 in total) will devote full-time participation during a ten-week research period and will gain an in-depth knowledge of biological concepts, modern research areas and tools. They will have the opportunity to choose basic, clinical, translational, or behavior research projects. The program will match talented medical students with NIH-funded faculty mentors, coupling the daily experience with an ongoing series of courses, summer research seminars, research-in-progress discussions, oral presentations, and monitoring from faculty members. The specific objectives are 1) to expose medical students early in their career to the excitement and technology of medical research and to foster their investigative and analytical skills;2) to encourage medical students to pursue a career in basic and clinical research in the areas of infectious diseases and inflammatory disorders;and 3) to provide valuable experience and references for students who wish to seek additional research training and funding in the future. An adequate tracking system is in place for monitoring the career development of trainees and the continued success of this training program. Our ultimate goal is to promote the professional development for our medical students, enhancing their skills in research, oral/written presentations and leaderships.

Public Health Relevance

This program will provide short-term, hands-on training for medical students in the area of infectious diseases and inflammatory disorders. It is designed to foster the interests of outstanding medical students in biomedical research and has successful outcomes in the first round of the funding period.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
NRSA Short -Term Research Training (T35)
Project #
2T35AI078878-06
Application #
8742251
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
2008-06-01
Project End
2019-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
6
Fiscal Year
2014
Total Cost
$28,233
Indirect Cost
$4,001
Name
University of Texas Medical Br Galveston
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Gupta, Akshaya; Yo, Jacob; Huang, Gengming et al. (2018) Developmental Defects Associated With DNA Copy Number Gain of Chromosome 2q33.1: A Case Report and Review of Literature. Lab Med 49:160-164
Liang, Yuejin; Yi, Panpan; Yuan, Denley Ming Kee et al. (2018) IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis. Cell Mol Immunol :
Soong, Lynn; Shelite, Thomas R; Xing, Yan et al. (2017) Type 1-skewed neuroinflammation and vascular damage associated with Orientia tsutsugamushi infection in mice. PLoS Negl Trop Dis 11:e0005765
Yi, Panpan; Liang, Yuejin; Yuan, Denley Ming Kee et al. (2017) A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection. Sci Rep 7:3857
Zhu, Shuang; Luo, Huanle; Liu, Hua et al. (2017) p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection. Antiviral Res 145:70-81
Soong, Lynn; Mendell, Nicole L; Olano, Juan P et al. (2016) An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection. PLoS Negl Trop Dis 10:e0004884
Grimes, Logan; Doyle, Allie; Miller, Aaron L et al. (2016) Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury. PLoS One 11:e0166770
Liang, Yuejin; Jie, Zuliang; Hou, Lifei et al. (2015) IL-33 promotes innate IFN-? production and modulates dendritic cell response in LCMV-induced hepatitis in mice. Eur J Immunol 45:3052-63
Gupta, Shivali; Silva, Trevor S; Osizugbo, Jessica E et al. (2014) Serum-mediated activation of macrophages reflects TcVac2 vaccine efficacy against Chagas disease. Infect Immun 82:1382-9
Gupta, Shivali; Wan, Xianxiu; Zago, Maria P et al. (2013) Antigenicity and diagnostic potential of vaccine candidates in human Chagas disease. PLoS Negl Trop Dis 7:e2018

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