Alcohol misuse is prevalent among persons living with HIV (PLWH) and associated with poor outcomes including less engagement in HIV care, more severe liver disease, and increased age-related comorbidities. Prior research on the intersection of alcohol and HIV has been conducted in relatively small samples or in select groups whose results may not be generalizable to the overall population of PLWH. The Alcohol Research Consortium in HIV?Epidemiology Research Arm (ARCH-ERA) was formed to investigate short and long-term effects of alcohol on clinical outcomes in the CFAR Network of Integrated Clinical Systems (CNICS). CNICS is an 8-site national network that is large, geographically and racially diverse, gender representative cohort of >31,000 PLWH in care. Careful outcomes adjudication, a large diverse population, and systematic longitudinal assessments of patient reported alcohol use, drug use, mental health symptoms, adherence, cognition, and other outcomes enables a rigorous approach to key questions on HIV and alcohol that are highly responsive to NIH HIV priorities: 1) disparities in HIV treatment outcomes; 2) HIV-associated comorbidities, neurological complications and aging. Capitalizing on the resources and infrastructure of CNICS, we propose the following aims: To examine longitudinal relationships of alcohol use, co- morbid drug use, and mental health disorders on the HIV Care Continuum; to determine longitudinal relationships between alcohol and liver disease progression in the era of direct acting antiretrovirals for hepatitis C virus treatment on liver disease outcomes; and to determine the impact of alcohol use on age-related comorbidities among PLWH in care. ARCH-ERA will continue to generate new knowledge on the intersection of HIV and alcohol to inform future research and clinical care in the US and globally.

Public Health Relevance

Alcohol misuse is prevalent among persons living with HIV (PLWH) and associated with poor outcomes including less engagement in HIV care , more severe liver disease, and increased age-related comorbidities. Identifying specific factors associated with alcohol misuse and its consequences will provide important information that will facilitate the design and implementation of interventions to mitigate the pervasive effects of misuse of alcohol on PLWH.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01AA020793-06
Application #
9205829
Study Section
Special Emphasis Panel (ZAA1-DD (10)V)
Program Officer
Roach, Deidra
Project Start
2011-09-20
Project End
2021-08-31
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
6
Fiscal Year
2016
Total Cost
$740,843
Indirect Cost
$166,707
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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