In response to RFA-AA-12-006, this application proposes the SRI International Research Component of the National Consortium on Alcohol and Neurodevelopment in Adolescence (N-CANDA) to determine the effects of alcohol use on the developing adolescent brain. Recruited at ages 12 through 21, a high risk enhanced community sample of 170 SRI subjects (N=680 from all sites) will complete a baseline assessment and undergo three annual follow-up assessments in an accelerated longitudinal design. At each visit, a multimodal magnetic resonance imaging (MRI) protocol, comprehensive neuropsychological battery, and assessments of alcohol and other substance use and related problems, mental health symptomatology, and substance use disorder risk factors will be measured. Brain imaging includes state-of-the-art high resolution structural MRI (sMRI), diffusion tensor imaging (DTI), and resting state MRI (rsMRI). The examination of alcohol consequences will focus on structural and functional maturation of brain areas that are actively developing during adolescence, involved in psychological regulation, responsive to rewards, and thought to be vulnerable to untoward alcohol effects. In addition, the SRI Research Component will collaborate on two additional studies. We will collaborate with Pittsburgh in a laboratory sleep study to examine the effects of adolescent heavy drinking on developmental trajectories of sleep EEG, a novel and sensitive marker of functional brain integrity. We will also collaborate with UCSD to study the effects of adolescent heavy drinking on default mode network integrity, and the extent to which this mediates cognitive performance, using functional connectivity analysis of data acquired in an fMRI protocol conducted during a Stroop Match-to-Sample Task. Studied in the context of risks and baseline brain characteristics, we will determine both the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent at heightened risk for an alcohol use disorder.

Public Health Relevance

Successful completion of the above aims will demonstrate that adolescent alcohol involvement disrupts brain development. This project represents a critical step in understanding neurobiological risks for accelerated alcohol use and alcohol effects on brain development in adolescence.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project--Cooperative Agreements (U01)
Project #
4U01AA021696-05
Application #
9069370
Study Section
Special Emphasis Panel (ZAA1)
Program Officer
Matochik, John A
Project Start
2012-09-05
Project End
2017-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
5
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Sri International
Department
Type
DUNS #
009232752
City
Menlo Park
State
CA
Country
United States
Zip Code
94025
de Zambotti, Massimiliano; Goldstone, Aimee; Colrain, Ian M et al. (2018) Insomnia disorder in adolescence: Diagnosis, impact, and treatment. Sleep Med Rev 39:12-24
de Zambotti, Massimiliano; Trinder, John; Silvani, Alessandro et al. (2018) Dynamic coupling between the central and autonomic nervous systems during sleep: A review. Neurosci Biobehav Rev 90:84-103
Goldstone, Aimée; Willoughby, Adrian R; de Zambotti, Massimiliano et al. (2018) The mediating role of cortical thickness and gray matter volume on sleep slow-wave activity during adolescence. Brain Struct Funct 223:669-685
Peterson, Eric T; Kwon, Dongjin; Luna, Beatriz et al. (2018) Distribution of brain iron accrual in adolescence: Evidence from cross-sectional and longitudinal analysis. Hum Brain Mapp :
Müller-Oehring, Eva M; Kwon, Dongjin; Nagel, Bonnie J et al. (2018) Influences of Age, Sex, and Moderate Alcohol Drinking on the Intrinsic Functional Architecture of Adolescent Brains. Cereb Cortex 28:1049-1063
Hasler, Brant P; Franzen, Peter L; de Zambotti, Massimiliano et al. (2017) Eveningness and Later Sleep Timing Are Associated with Greater Risk for Alcohol and Marijuana Use in Adolescence: Initial Findings from the National Consortium on Alcohol and Neurodevelopment in Adolescence Study. Alcohol Clin Exp Res 41:1154-1165
de Zambotti, Massimiliano; Rosas, Leonardo; Colrain, Ian M et al. (2017) The Sleep of the Ring: Comparison of the ?URA Sleep Tracker Against Polysomnography. Behav Sleep Med :1-15
Clark, Duncan B; Chung, Tammy; Martin, Christopher S et al. (2017) Adolescent Executive Dysfunction in Daily Life: Relationships to Risks, Brain Structure and Substance Use. Front Behav Neurosci 11:223
Sullivan, Edith V; Lane, Barton; Kwon, Dongjin et al. (2017) Structural brain anomalies in healthy adolescents in the NCANDA cohort: relation to neuropsychological test performance, sex, and ethnicity. Brain Imaging Behav 11:1302-1315
Sullivan, Edith V; Brumback, Ty; Tapert, Susan F et al. (2017) Effects of prior testing lasting a full year in NCANDA adolescents: Contributions from age, sex, socioeconomic status, ethnicity, site, family history of alcohol or drug abuse, and baseline performance. Dev Cogn Neurosci 24:72-83

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