Abstract

The goal of this proposal is to establish a population based registry of patients with Alzheimer's type dementia (DAT) and other dementias and to collect epidemiologic, genetic (pedigree), and clinical information for the investigation of etiologic factors related to DAT. Group Health Cooperative (GHC) central membership (approx. 25,000 over age 60) will form the population base. Incident cases of probable dementia presenting to GHC facilities will be identified, screened, and diagnostically evaluated. Approximately 150 of the projected 230 new dementia cases occurring yearly are expected to DAT. Since the registry is population based, incidence rates can be calculated. Sensitivity and specificity of the screening device will be evaluated; eventually accuracy of the clinical diagnosis also will be evaluable because neuropathologic data will be collected for validation of the clinical diagnosis of DAT. This registry will serve as the primary resource for future population based studies of the etiology of DAT and other types of dementia in conjunction with the University of Washington Alzheimer's Disease Research Center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AG006781-02
Application #
3546259
Study Section
Aging Review Committee (AGE)
Project Start
1986-09-30
Project End
1989-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Harding, Barbara N; Weiss, Noel S; Walker, Rod L et al. (2018) Proton pump inhibitor use and the risk of fractures among an older adult cohort. Pharmacoepidemiol Drug Saf 27:596-603
Keene, C Dirk; Wilson, Angela M; Kilgore, Mitchell D et al. (2018) Luminex-based quantification of Alzheimer's disease neuropathologic change in formalin-fixed post-mortem human brain tissue. Lab Invest :
Flanagan, Margaret E; Larson, Eric B; Walker, Rod L et al. (2018) Associations between Use of Specific Analgesics and Concentrations of Amyloid-? 42 or Phospho-Tau in Regions of Human Cerebral Cortex. J Alzheimers Dis 61:653-662
Gray, Shelly L; Anderson, Melissa L; Hanlon, Joseph T et al. (2018) Exposure to Strong Anticholinergic Medications and Dementia-Related Neuropathology in a Community-Based Autopsy Cohort. J Alzheimers Dis 65:607-616
Marcum, Zachary A; Walker, Rod; Bobb, Jennifer F et al. (2018) Serum Cholesterol and Incident Alzheimer's Disease: Findings from the Adult Changes in Thought Study. J Am Geriatr Soc 66:2344-2352
Moreno, Monica A; Or-Geva, Noga; Aftab, Blake T et al. (2018) Molecular signature of Epstein-Barr virus infection in MS brain lesions. Neurol Neuroimmunol Neuroinflamm 5:e466
Condello, Carlo; Lemmin, Thomas; Stöhr, Jan et al. (2018) Structural heterogeneity and intersubject variability of A? in familial and sporadic Alzheimer's disease. Proc Natl Acad Sci U S A 115:E782-E791
Gray, Shelly L; Hart, Laura A; Perera, Subashan et al. (2018) Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults. J Am Geriatr Soc 66:282-288
Bagi, Zsolt; Brandner, Dieter D; Le, Phuong et al. (2018) Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter. Ann Neurol 83:142-152
Locke, Timothy M; Soden, Marta E; Miller, Samara M et al. (2018) Dopamine D1 Receptor-Positive Neurons in the Lateral Nucleus of the Cerebellum Contribute to Cognitive Behavior. Biol Psychiatry 84:401-412

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