The University of Washington Alzheimer's Disease Patient Registry (ADPR) is a model clinical and epidemiologic database for dementia and dementia of the Alzheimer's type (DAT). It was established in late 1986 by a grant from the National Institute on Aging and is based in a large health maintenance organization -- Group Health Cooperative of Puget Sound (GHC). The ADPR enrolls only those cases of dementia and DAT who have come to medical attention since 1 January 1987; providing each of the potential cases with a standardized, physical, neurological and neuropsychological examination leading to a criteria-based diagnosis. The goal of this application is to continue the model ADPR for another three years so that additional cases can be enrolled; additional cases will allow ongoing epidemiologic/genetic studies to proceed and make future investigations feasible.
The specific aims of the project are: 1. To identify GHC patients who come to medical attention for (previously undiagnosed) dementia and to provide each of these patients with a standardized, thorough examination for dementia and to assign based on established criteria; 2. To enroll the identified patients in the ADPR and to maintain a detailed database including epidemiologic, clinical and family history data; this database will provide cases for other investigations especially concerning diagnosis, etiology and risk factors for DAT and other dementias; 3. To describe the course of dementia, in particular DAT, in terms of cognitive and functional decline, survival and clinical- pathologic correlations. 4. To compare the annual case identification rate of dementia and DAT from the GHC population base with published estimates of incidence.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01AG006781-04A1
Application #
3546256
Study Section
Aging Review Committee (AGE)
Project Start
1986-09-30
Project End
1993-03-31
Budget Start
1990-05-01
Budget End
1991-03-31
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
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