The primary aim of the Health and Retirement Study (HRS) cooperative agreement is to collect and distribute multi-disciplinary data to support research on aging. Cognitive impairment and dementia, for which Alzheimer's disease is the principal cause either alone or in combination with other factors, impose enormous burdens on families and government policies. Population-based studies can complement clinical studies to enhance understanding of the etiology and impact of dementia. With consistent measurement, trends over time and variation across countries can further expand our knowledge. This revision application, in response to NIA notice NOT-AG-14-022, aims to build on prior work in the HRS and its previous dementia sub-study, the Aging, Demographics, and Memory Study (ADAMS) to implement a cost-effective algorithmic approach to assessing cognitive impairment and dementia. This new Harmonized Cognitive Assessment Protocol (HCAP) will provide a basis for comparing trends over time in the US and for comparison across countries with HRS-like longitudinal studies of aging. The proposed sample of 3,000 persons aged 65 and older drawn from the HRS will create the potential for longitudinal follow-up to observe trajectories of decline and study their correlates in the rich data collected by HRS. We also propose to collect and store samples of venous blood from HCAP participants for future use.

Public Health Relevance

This revision to the Health and Retirement Study aims to conduct a new population study of dementia of 3000 persons aged 65 and older from the HRS sample. The harmonized cognitive assessment protocol (HCAP) will allow analysis of trends by comparison with the HRS ADAMS study of over ten years ago, and international comparisons with other studies using similar protocols. This will support new research on the causes and consequences of dementia, the most burdensome of all age-related diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01AG009740-26S3
Application #
8964263
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Patmios, Georgeanne E
Project Start
1998-01-01
Project End
2017-12-31
Budget Start
2015-09-01
Budget End
2015-12-31
Support Year
26
Fiscal Year
2015
Total Cost
$2,576,263
Indirect Cost
$640,108
Name
University of Michigan Ann Arbor
Department
Miscellaneous
Type
Organized Research Units
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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