This is an application for a Clinical Site in response to RFA AG-94-002. We have studied the menopausal transition in a sample of 541 initially healthy women, predominantly middle- and upper middle-class. Although the number of African American women and women with a high school education or less were in the minority in our sample, they had unique characteristics at study entry and experienced unique changes during the follow-up period. We now propose to recruit 450 premenopausal women of middle and lower class socioeconomic status into a longitudinal study of the menopausal transition; 150 of them will be African American. Women will be evaluated at study entry and at 4 (perimenopause) and 12 months (postmenopause) after the cessation of menses. Matched by age and race to peri- and post-menopausal women, premenopausal women will be evaluated at the same time to serve as controls for aging, seasonality, and repeat testing. With this study design, we will evaluate the hypotheses that independent of aging, change in reproductive hormones, marked by cessation of menses, leads to alterations in levels of lipids and lipoproteins, susceptibility to lipid peroxidation; cardiovascular responses to behavioral challenge; carotid artery vessel compliance and distensibility; endothelial function in the brachial artery; bone mass of the proximal femur, lumbar spine, and total body calcium; body composition; production of pro-inflammatory cytokines; health behaviors; and rates of clinical episodes of depression or anxiety and levels of depressive symptoms. We will compare the magnitude of changes in the above according to race and social class, as measured by educational attainment, and will test specific hypotheses about the interrelationships among the changes, e.g. changes in bone and correlated with changes in cytokines; changes in cardiovascular responses to stress are related to changes in compliance, distensibility, endothelial function, and LDL oxidative susceptibility. Little is known about the menopausal transition, especially in Africa American women and women of lower socioeconomic status, and this proposal aims to supply important missing information.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01AG012546-01
Application #
2054199
Study Section
Special Emphasis Panel (ZAG1-BJB-1 (01))
Project Start
1994-09-30
Project End
1999-07-31
Budget Start
1994-09-30
Budget End
1995-07-31
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Crawford, Sybil L; Crandall, Carolyn J; Derby, Carol A et al. (2018) Menopausal hormone therapy trends before versus after 2002: impact of the Women's Health Initiative Study Results. Menopause :
Karlamangla, Arun S; Burnett-Bowie, Sherri-Ann M; Crandall, Carolyn J (2018) Bone Health During the Menopause Transition and Beyond. Obstet Gynecol Clin North Am 45:695-708
Beatty Moody, Danielle L; Chang, Yuefang; Brown, Charlotte et al. (2018) Everyday Discrimination and Metabolic Syndrome Incidence in a Racially/Ethnically Diverse Sample: Study of Women's Health Across the Nation. Psychosom Med 80:114-121
Yoshida, Kazuki; Yu, Zhi; Greendale, Gail A et al. (2018) Effects of analgesics on bone mineral density: A longitudinal analysis of the prospective SWAN cohort with three-group matching weights. Pharmacoepidemiol Drug Saf 27:182-190
Bromberger, Joyce T; Epperson, Cynthia Neill (2018) Depression During and After the Perimenopause: Impact of Hormones, Genetics, and Environmental Determinants of Disease. Obstet Gynecol Clin North Am 45:663-678
Waetjen, L Elaine; Xing, Guibo; Johnson, Wesley O et al. (2018) Factors associated with reasons incontinent midlife women report for not seeking urinary incontinence treatment over 9 years across the menopausal transition. Menopause 25:29-37
Allshouse, Amanda A; Santoro, Nanette; Green, Robin et al. (2018) Religiosity and faith in relation to time to metabolic syndrome for Hispanic women in a multiethnic cohort of women-Findings from the Study of Women's Health Across the Nation (SWAN). Maturitas 112:18-23
Allshouse, Amanda; Pavlovic, Jelena; Santoro, Nanette (2018) Menstrual Cycle Hormone Changes Associated with Reproductive Aging and How They May Relate to Symptoms. Obstet Gynecol Clin North Am 45:613-628
Hanley, Carrie; Shields, Kelly J; Matthews, Karen A et al. (2018) Associations of cardiovascular fat radiodensity and vascular calcification in midlife women: The SWAN cardiovascular fat ancillary study. Atherosclerosis 279:114-121
Chyu, Laura; Upchurch, Dawn M (2018) A Longitudinal Analysis of Allostatic Load among a Multi-Ethnic Sample of Midlife Women: Findings from the Study of Women's Health Across the Nation. Womens Health Issues 28:258-266

Showing the most recent 10 out of 426 publications