Five years of support are requested by the NERI to become a coordinating center for sites which conduct clinical trials to develop cognitive and other interventions to help older persons maintain independence for longer periods of time. The overall goal of this cooperative multisite field trial is to test the efficacy of a cognitive or related perceptual, motivational, or attitudinal intervention in promoting independent functioning in a diverse group of at-risk older adults. More specifically, the aims of this field trial include 1) designing a common cognitive intervention appropriate for the target population; 2) designing an evaluation strategy to assess the efficacy of the intervention; and 3) implementing the intervention and conducting a randomized trial to determine efficacy. This coordinating center will provide leadership and expertise in the following areas: 1) providing technical assistance in designing and evaluating the intervention, including development of a core measurement battery; 2) designing a data management system for use by the field centers, including training and monitoring of their staff; 3) developing quality control activities, including development of a manual of operations and forms, and training and monitoring of the field staff to ensure standard implementation of the common protocol across the sites; 4) monitoring data acquisition to ensure high quality databases for analyses; 5) primary analyses of trial outcomes, including integration of process measures to assess treatment fidelity; and 6) communication and meeting support. The NERI investigators have previously conducted coordination-center activities in complex multisite trials. In addition, the NERI has equipment and expertise required for the design and analysis of non-standard trials with process measure integration and data management systems (centralized and distributed) and randomization.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AG014282-05
Application #
6169444
Study Section
Special Emphasis Panel (ZAG1-DAG-9 (O9))
Program Officer
Nielsen, Lisbeth
Project Start
1996-09-30
Project End
2003-06-30
Budget Start
2000-07-01
Budget End
2003-06-30
Support Year
5
Fiscal Year
2000
Total Cost
$379,143
Indirect Cost
Name
New England Research Institute
Department
Type
DUNS #
153914080
City
Watertown
State
MA
Country
United States
Zip Code
02472
Ross, Lesley A; Sprague, Briana N; Phillips, Christine B et al. (2018) The Impact of Three Cognitive Training Interventions on Older Adults' Physical Functioning Across 5 Years. J Aging Health 30:475-498
Tomaszewski Farias, Sarah; Giovannetti, Tania; Payne, Brennan R et al. (2018) Self-perceived Difficulties in Everyday Function Precede Cognitive Decline among Older Adults in the ACTIVE Study. J Int Neuropsychol Soc 24:104-112
Ross, Lesley A; Freed, Sara A; Edwards, Jerri D et al. (2017) The Impact of Three Cognitive Training Programs on Driving Cessation Across 10 Years: A Randomized Controlled Trial. Gerontologist 57:838-846
Meyer, Oanh L; Sisco, Shannon M; Harvey, Danielle et al. (2017) Neighborhood Predictors of Cognitive Training Outcomes and Trajectories in ACTIVE. Res Aging 39:443-467
Parisi, Jeanine M; Gross, Alden L; Marsiske, Michael et al. (2017) Control beliefs and cognition over a 10-year period: Findings from the ACTIVE trial. Psychol Aging 32:69-75
Thomas, Kelsey R; Marsiske, Michael (2017) Age trajectories of everyday cognition in African American and White older adults under prompted and unprompted conditions. Neuropsychol Rehabil 27:522-539
Ross, Lesley A; Edwards, Jerri D; O'Connor, Melissa L et al. (2016) The Transfer of Cognitive Speed of Processing Training to Older Adults' Driving Mobility Across 5 Years. J Gerontol B Psychol Sci Soc Sci 71:87-97
Choi, Moon; O'Connor, Melissa L; Mingo, Chivon A et al. (2016) Gender and Racial Disparities in Life-Space Constriction Among Older Adults. Gerontologist 56:1153-1160
Phillips, Christine B; Sprague, Briana N; Freed, Sara A et al. (2016) Longitudinal Associations Between Changes in Physical Function and Driving Mobility Behaviors of Older Adults. Transp Res Rec 2584:70-76
Zahodne, Laura B; Meyer, Oanh L; Choi, Eunhee et al. (2015) External locus of control contributes to racial disparities in memory and reasoning training gains in ACTIVE. Psychol Aging 30:561-72

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