This competing renewal application is to provide for ontinued maintenance of and activities associated with the SWAN Repositories of serum, plasma, urine, DNA and transformed cells generated from a 10-year study of a population of 3302 women from 5 ethnic groups who have been evaluated annually prior to, during and following the menopausal transition. These Repositories, an arm of the Study of Women's Health Across the Nation (SWAN), are meant to support, facilitate and extend the Core SWAN;additionally, the Repositories provide a mechanism for opening the resources of SWAN to the greater scientific community. Implementing activities associated with three proposed specific aims of this competing renewal will 1) provide for the continued management of the current 1.7 million Repository specimens and the additional specimens that will accrue as a result of fielding SWAN IV in 2009 to 2014;2) expand the DNA Repository, the most frequently requested specimen type that is uniquely renewable because of our investment in cell immortalization;3) promote effective information interchange about the SWAN Study, its data and the Repository resources through development of a 2-level web-based """"""""data warehouse"""""""";4) provide for continued administration of the application review process for specimen utilization and administrative management of specimen distribution including Material Transfer Agreements;5) engage in strategies to promote utilization of specimens;and, 6) expand the scope of the genetics studies associated with the SWAN study and its Repository.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01AG017719-11A2S1
Application #
8285420
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Sherman, Sherry
Project Start
2000-07-01
Project End
2015-08-31
Budget Start
2011-07-01
Budget End
2011-08-31
Support Year
11
Fiscal Year
2011
Total Cost
$517,000
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Beatty Moody, Danielle L; Chang, Yuefang; Brown, Charlotte et al. (2018) Everyday Discrimination and Metabolic Syndrome Incidence in a Racially/Ethnically Diverse Sample: Study of Women's Health Across the Nation. Psychosom Med 80:114-121
Everson-Rose, Susan A; Clark, Cari J; Wang, Qi et al. (2018) Depressive symptoms and adipokines in women: Study of women's health across the nation. Psychoneuroendocrinology 97:20-27
Hine, J L; de Lusignan, S; Burleigh, D et al. (2017) Association between glycaemic control and common infections in people with Type 2 diabetes: a cohort study. Diabet Med 34:551-557
Matthews, Karen A; El Khoudary, Samar R; Brooks, Maria M et al. (2017) Lipid Changes Around the Final Menstrual Period Predict Carotid Subclinical Disease in Postmenopausal Women. Stroke 48:70-76
Baker, Jessica H; Peterson, Claire M; Thornton, Laura M et al. (2017) Reproductive and Appetite Hormones and Bulimic Symptoms during Midlife. Eur Eat Disord Rev 25:188-194
Pastore, Lisa M; Young, Steven L; Manichaikul, Ani et al. (2017) Distribution of the FMR1 gene in females by race/ethnicity: women with diminished ovarian reserve versus women with normal fertility (SWAN study). Fertil Steril 107:205-211.e1
Park, S K; Harlow, S D; Zheng, H et al. (2017) Association between changes in oestradiol and follicle-stimulating hormone levels during the menopausal transition and risk of diabetes. Diabet Med 34:531-538
Basu, Sumanta; Duren, William; Evans, Charles R et al. (2017) Sparse network modeling and metscape-based visualization methods for the analysis of large-scale metabolomics data. Bioinformatics 33:1545-1553
Shieh, Albert; Ishii, Shinya; Greendale, Gail A et al. (2016) Urinary N-telopeptide and Rate of Bone Loss Over the Menopause Transition and Early Postmenopause. J Bone Miner Res 31:2057-2064

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