There has long been an appreciation of the importance of osteoporosis in women, and decades of research have yielded a strong foundation of mechanistic and practical knowledge that underlies clinical decision-making. On the other hand, very little information is available to direct the management of osteoporosis in men. Data are gradually emerging, but are derived primarily from cross sectional studies and remain fragmentary. The motivation for this proposal is to provide the essential groundwork for rational clinical and public health decisions concerning osteoporosis in men, and to direct future studies of pathophysiology and therapeutics. UCSF will serve as the Coordinating Center for the six clinical centers. These centers will recruit approximately 5700 older men, characterize selected variables of probable importance to skeletal health, and to identify the major determinants of fracture risk over a 3+ year follow-up period. The proposed study will adopt measures that are in many ways identical to those utilized in the Study of Osteoporotic Fractures, an ongoing, large, longitudinal observational study of the determinants of fracture risk in women conducted by the current investigative team and led by the UCSF CC). The UCSF Coordinating Center has had extensive experience in coordinating a number of large NIH and industry sponsored multicenter studies of osteoporosis that are directly relevant to the proposed study in men. UCSF-coordinated studies include the Study of Osteoporotic Fractures, the Fracture Intervention Trial the Fracture Intervention Trial Extension (FLEX), the Health, Aging and Body Changes (Health ABC) study, the Multiple Outcomes of Raloxifene Evaluation Trial (MORE), and osteoporosis-related functions of the Women's Health Initiative (WHI). As we have for other studies, we will provide comprehensive operations manuals, clear scannable data collection instruments, expert training, convenient communications systems, state of the art data management system, experienced management of all aspects of densitometry, skeletal radiology, and QCT assessments and quality control. The end product will be well documented distributed data sets for analysis and production of landmark papers about skeletal health in men.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AG018197-05
Application #
6644738
Study Section
Special Emphasis Panel (ZAR1-JRL-A (O3))
Program Officer
Sherman, Sherry
Project Start
1999-09-30
Project End
2004-06-30
Budget Start
2003-08-15
Budget End
2004-06-30
Support Year
5
Fiscal Year
2003
Total Cost
$865,750
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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Raman, Dileep; Kaffashi, Farhad; Lui, Li-Yung et al. (2017) Polysomnographic Heart Rate Variability Indices and Atrial Ectopy Associated with Incident Atrial Fibrillation Risk in Older Community-dwelling Men. JACC Clin Electrophysiol 3:451-460
Campos-Obando, Natalia; Koek, W Nadia H; Hooker, Elizabeth R et al. (2017) Serum Phosphate Is Associated With Fracture Risk: The Rotterdam Study and MrOS. J Bone Miner Res 32:1182-1193
Hooker, Elizabeth R; Shrestha, Smriti; Lee, Christine G et al. (2017) Obesity and Falls in a Prospective Study of Older Men: The Osteoporotic Fractures in Men Study. J Aging Health 29:1235-1250
Katzman, Wendy B; Huang, Mei-Hua; Kritz-Silverstein, Donna et al. (2017) Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Impaired Physical Function: The Rancho Bernardo Study. J Am Geriatr Soc 65:1476-1481
Ben-Avraham, Dan; Karasik, David; Verghese, Joe et al. (2017) The complex genetics of gait speed: genome-wide meta-analysis approach. Aging (Albany NY) 9:209-246
Nielson, Carrie M; Wiedrick, Jack; Shen, Jian et al. (2017) Identification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics. J Bone Miner Res 32:1559-1567
Laddu, Deepika R; Cawthon, Peggy M; Parimi, Neeta et al. (2017) Trajectories of the relationships of physical activity with body composition changes in older men: the MrOS study. BMC Geriatr 17:119
Rogers, Tara S; Blackwell, Terri L; Lane, Nancy E et al. (2017) Rest-activity patterns and falls and fractures in older men. Osteoporos Int 28:1313-1322
Napoli, Nicola; Schafer, Anne L; Lui, Li-Yung et al. (2016) Serum 25-hydroxyvitamin D level and incident type 2 diabetes in older men, the Osteoporotic Fractures in Men (MrOS) study. Bone 90:181-4

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