Abstract

The purpose of this proposal is to request support for an established, highly efficient AIDS Clinical Trials Unit that serves a 5.4 million population region accounting for 47% of all AIDS cases in Ohio. Project 0004 proposes continuation of Adult Clinical Trials activities in Cleveland and in our Toledo subunit. A new subunit will be established at MetroHealth Medical Center, a county hospital and major HIV care provider in Cleveland, serving large African-American and Hispanic communities. Project 0005 is designed to continue availability of Pediatrics AIDS Clinical Trials in Cleveland. Project 9001 will support the continuation of our HIV Virology laboratory that has been a leader in the ACTG effort in terms of cost efficiency, quality performance and assay development. Project 0006 is a proposal to develop polymerase-chain-reaction (PCR) based techniques for quantification of viral load in clinical samples and for accurate diagnosis of neonatal HIV infection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI025879-07
Application #
2063130
Study Section
Special Emphasis Panel (SRC (61))
Project Start
1987-09-30
Project End
1996-01-31
Budget Start
1994-02-01
Budget End
1995-01-31
Support Year
7
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Chang, J Judy; Woods, Matt; Lindsay, Robert J et al. (2013) Higher expression of several interferon-stimulated genes in HIV-1-infected females after adjusting for the level of viral replication. J Infect Dis 208:830-8
Kyeyune, Fred; Nankya, Immaculate; Metha, Samar et al. (2013) Treatment failure and drug resistance is more frequent in HIV-1 subtype D versus subtype A-infected Ugandans over a 10-year study period. AIDS 27:1899-909
Imamichi, Hiromi; Degray, Gerald; Asmuth, David M et al. (2011) HIV-1 viruses detected during episodic blips following interleukin-7 administration are similar to the viruses present before and after interleukin-7 therapy. AIDS 25:159-64
Anthony, D D; Umbleja, T; Aberg, J A et al. (2011) Lower peripheral blood CD14+ monocyte frequency and higher CD34+ progenitor cell frequency are associated with HBV vaccine induced response in HIV infected individuals. Vaccine 29:3558-63
Tebit, Denis M; Lobritz, Michael; Lalonde, Matthew et al. (2010) Divergent evolution in reverse transcriptase (RT) of HIV-1 group O and M lineages: impact on structure, fitness, and sensitivity to nonnucleoside RT inhibitors. J Virol 84:9817-30
Lok, Judith J; Bosch, Ronald J; Benson, Constance A et al. (2010) Long-term increase in CD4+ T-cell counts during combination antiretroviral therapy for HIV-1 infection. AIDS 24:1867-76
Kalayjian, Robert C (2010) The treatment of HIV-associated nephropathy. Adv Chronic Kidney Dis 17:59-71
Winham, Stacey J; Slater, Andrew J; Motsinger-Reif, Alison A (2010) A comparison of internal validation techniques for multifactor dimensionality reduction. BMC Bioinformatics 11:394
Lassen, Kara G; Lobritz, Michael A; Bailey, Justin R et al. (2009) Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics. PLoS Pathog 5:e1000377
Robbins, Gregory K; Spritzler, John G; Chan, Ellen S et al. (2009) Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384. Clin Infect Dis 48:350-61

Showing the most recent 10 out of 116 publications