Abstract

The HIV-1 epidemic has had a major impact upon the urban centers of the United States now being the leading cause of death among men 25-44 years of age and the fourth leading cause of death in women in the same age group. The demographics of persons with AIDS in Chicago, reported to the CDC, reflect the increasing impact of the epidemic among women, the African-American and Hispanic/Latino communities. The Chicago AIDS Clinical Trials Unit plans to participate in AIDS Clinical Trials Group (ACTG) protocols that are hypothesis-based and pathogenesis-oriented and that are designed to evaluate therapy of the primary human immunodeficiency virus type-1 infection, the management and prevention of the infectious, oncologic and neurologic complications of the retrovirus infection and the immunologic treatment modalities.
Specific aims i nclude: 1. participation in phase I, II and III trials of anti-retroviral agents. 2. participation in immune based therapy trials. 3. participation in trials evaluating prophylaxis and treatment of opportunistic infections and in therapeutic protocols for malignant and neurologic complications of HIV-1 infection. 4. Maintenance of a preparative laboratory to support ACTG protocol mandated virologic and pharmacologic assays. 5. Continued maintenance of the capability to conduct core immunologic studies mandated by ACTG protocols. 6. Continued efforts to enroll women and members of underrepresented populations in ACTG protocols.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI025915-12
Application #
2633467
Study Section
Special Emphasis Panel (SRC (56))
Project Start
1987-09-30
Project End
1999-12-31
Budget Start
1998-01-01
Budget End
1998-12-31
Support Year
12
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Kelesidis, Theodoros; Tran, Thuy Tien T; Stein, James H et al. (2015) Changes in Inflammation and Immune Activation With Atazanavir-, Raltegravir-, Darunavir-Based Initial Antiviral Therapy: ACTG 5260s. Clin Infect Dis 61:651-60
Safren, Steven A; Biello, Katie B; Smeaton, Laura et al. (2014) Psychosocial predictors of non-adherence and treatment failure in a large scale multi-national trial of antiretroviral therapy for HIV: data from the ACTG A5175/PEARLS trial. PLoS One 9:e104178
Sacktor, Ned; Miyahara, Sachiko; Evans, Scott et al. (2014) Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. J Neurovirol 20:620-6
Hulgan, Todd; Stein, James H; Cotter, Bruno R et al. (2013) Mitochondrial DNA variation and changes in adiponectin and endothelial function in HIV-infected adults after antiretroviral therapy initiation. AIDS Res Hum Retroviruses 29:1293-9
Safren, Steven A; Hendriksen, Ellen S; Smeaton, Laura et al. (2012) Quality of life among individuals with HIV starting antiretroviral therapy in diverse resource-limited areas of the world. AIDS Behav 16:266-77
Chaplin, B; Eisen, G; Idoko, J et al. (2011) Impact of HIV type 1 subtype on drug resistance mutations in Nigerian patients failing first-line therapy. AIDS Res Hum Retroviruses 27:71-80
Grinsztejn, Beatriz; Smeaton, Laura; Barnett, Ronald et al. (2011) Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell count. Antivir Ther 16:1057-62
Grady, Benjamin J; Torstenson, Eric S; McLaren, Paul J et al. (2011) Use of biological knowledge to inform the analysis of gene-gene interactions involved in modulating virologic failure with efavirenz-containing treatment regimens in ART-naïve ACTG clinical trials participants. Pac Symp Biocomput :253-64
Cohn, Susan E; Jiang, Hongyu; McCutchan, J Allen et al. (2011) Association of ongoing drug and alcohol use with non-adherence to antiretroviral therapy and higher risk of AIDS and death: results from ACTG 362. AIDS Care 23:775-85
Sacktor, N; Miyahara, S; Deng, L et al. (2011) Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trial. Neurology 77:1135-42

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