Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI026075-04
Application #
3547089
Study Section
Special Emphasis Panel (SRC (21))
Project Start
1988-04-01
Project End
1991-06-30
Budget Start
1991-04-01
Budget End
1991-06-30
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Henry M. Jackson Fdn for the Adv Mil/Med
Department
Type
DUNS #
City
Rockville
State
MD
Country
United States
Zip Code
20817
Tusell, Sonia M; Schittone, Stephanie A; Holmes, Kathryn V (2007) Mutational analysis of aminopeptidase N, a receptor for several group 1 coronaviruses, identifies key determinants of viral host range. J Virol 81:1261-73
Wentworth, David E; Tresnan, D B; Turner, B C et al. (2005) Cells of human aminopeptidase N (CD13) transgenic mice are infected by human coronavirus-229E in vitro, but not in vivo. Virology 335:185-97
Breslin, Jamie J; Mork, Irene; Smith, M K et al. (2003) Human coronavirus 229E: receptor binding domain and neutralization by soluble receptor at 37 degrees C. J Virol 77:4435-8
Tan, Kemin; Zelus, Bruce D; Meijers, Rob et al. (2002) Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family. EMBO J 21:2076-86
Blau, D M; Holmes, K V (2001) Human coronavirus HCoV-229E enters susceptible cells via the endocytic pathway. Adv Exp Med Biol 494:193-8
Wentworth, D E; Holmes, K V (2001) Molecular determinants of species specificity in the coronavirus receptor aminopeptidase N (CD13): influence of N-linked glycosylation. J Virol 75:9741-52
Wentworth, D E; Holmes, K V (2001) Addition of a single glycosylation site to hAPN blocks human coronavirus-229E receptor activity. Adv Exp Med Biol 494:199-204
Robitaille, J; Izzi, L; Daniels, E et al. (1999) Comparison of expression patterns and cell adhesion properties of the mouse biliary glycoproteins Bbgp1 and Bbgp2. Eur J Biochem 264:534-44
Tresnan, D B; Holmes, K V (1998) Feline aminopeptidase N is a receptor for all group I coronaviruses. Adv Exp Med Biol 440:69-75
Wessner, D R; Shick, P C; Lu, J H et al. (1998) Mutational analysis of the virus and monoclonal antibody binding sites in MHVR, the cellular receptor of the murine coronavirus mouse hepatitis virus strain A59. J Virol 72:1941-8

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