The UCSD Retrovirology Laboratory is an integral part of the UCSD Pediatric ACTU and has played an important role in the success of the AIDS Clinical Trials Program in San Diego.
The Specific Aims of the Retrovirology Laboratory are: (1) To apply standardized, reproducible, and quality-controlled assays of HIV infection as virologic markers in children participating in ACTG protocols; (2) To provide essential virologic data to help guide clinical investigators in determining the scientific direction of antiretroviral studies and to determine whether an infant is HIV-infected; (3) To evaluate the utility of new virologic assays for monitoring the response of children participating in antiretroviral studies; and (4) To assist in the development of novel virologic assays which can be applied to monitor patients receiving antiretroviral therapy by providing well-characterized and properly stored specimens including serum, plasma, peripheral blood mononuclear cells, and primary viral isolates. The Laboratory is fully certified to perform qualitative and quantitative HIV cultures of peripheral blood mononuclear cells and plasma and to perform p24 antigen and PCR assays. The overall objective of the UCSD Retrovirology Laboratory in this proposal is to provide virologic data that can be used to assist in the evaluation of patients participating in ACTG studies and thus, improve therapy for HIV-infected women and children.

Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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Saitoh, Akihiko; Foca, Marc; Viani, Rolando M et al. (2008) Clinical outcomes after an unstructured treatment interruption in children and adolescents with perinatally acquired HIV infection. Pediatrics 121:e513-21
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Saitoh, Akihiko; Sarles, Elizabeth; Capparelli, Edmund et al. (2007) CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children. AIDS 21:2191-9
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Saitoh, Akihiko; Fletcher, Courtney V; Brundage, Richard et al. (2007) Efavirenz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516T polymorphism. J Acquir Immune Defic Syndr 45:280-5
Seage 3rd, George R; Buchacz, Kate; Weinberg, Geoffrey A et al. (2006) The Pediatric AIDS Severity Score (PASS): a multidimensional AIDS-severity adjustment for pediatric HIV infection. J Acquir Immune Defic Syndr 43:603-10
Patel, Kunjal; Weinberg, Geoffrey A; Buchacz, Kate et al. (2006) Simple Pediatric AIDS Severity Score (PASS): a pediatric severity score for resource-limited settings. J Acquir Immune Defic Syndr 43:611-7
Saitoh, Akihiko; Singh, Kumud K; Sandall, Sharsti et al. (2006) Association of CD4+ T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy. J Allergy Clin Immunol 117:909-15

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