The primary objective of this proposal is to continue the strong participation of the USC ACTU in developmental therapeutics in HIV positive persons in priority areas: primary infection; opportunistic infections; oncology; and neurologic complications. The USC ACTU was one of the original 13 ACTUs with inception in 1986. Through July 2, 1991 the USC ACTU had accrued 872 patients to various ACTU protocols. In the current proposal, it is planned to accrue a total of 150 new patients per year distributed among the four priority areas mentioned above. To achieve this overall goal, USC has applied for several of the components listed in the RFA. The work subsumed under Part A, Adult Clinical Trials Unit, will cover the recruitment, clinical evaluation, and follow up of patients as well as the required immunologic tests. USC has a strong and experienced retrovirology laboratory, very well coordinated and integrated with the clinical ACTU. Therefore, proposals under Part C, C.1, protocol mandated virology, and under Part C, C.3, developmental virologic research, have been submitted. The USC faculty has a major interest in clinical pharmacology. Therefore proposals have been submitted under part C.2 of the RFA to conduct protocol mandated pharmacology laboratory tests.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI027673-07
Application #
3547465
Study Section
Special Emphasis Panel (SRC (35))
Project Start
1992-03-01
Project End
1995-02-28
Budget Start
1993-01-01
Budget End
1993-12-31
Support Year
7
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
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