Abstract

This project, which is submitted for its second competitive renewal, has been directed toward an understanding of disease susceptibility as it relates to HLA and T cell receptor genes. Here we extend these studies to a comprehensive analysis of the critical T cell target antigens in the two disease models we have studied to date: insulin dependent diabetes mellitus (IDDM) and rheumatoid arthritis (RA). Additionally, we will extend susceptibility studies to the peptide transporter genes with a focus on TAP-1. Finally, we will attempt to isolate peptides from MHC molecules in both disease models.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI034621-02
Application #
3747480
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

Zwirner, N W; Marcos, C Y; Mirbaha, F et al. (2000) Identification of MICA as a new polymorphic alloantigen recognized by antibodies in sera of organ transplant recipients. Hum Immunol 61:917-24
Lin, M S; Fu, C L; Aoki, V et al. (2000) Desmoglein-1-specific T lymphocytes from patients with endemic pemphigus foliaceus (fogo selvagem). J Clin Invest 105:207-13
Zwirner, N W; Dole, K; Stastny, P (1999) Differential surface expression of MICA by endothelial cells, fibroblasts, keratinocytes, and monocytes. Hum Immunol 60:323-30
Boackle, S A; Morris, M A; Holers, V M et al. (1998) Complement opsonization is required for presentation of immune complexes by resting peripheral blood B cells. J Immunol 161:6537-43
Forero, L; Zwirner, N W; Fink, C W et al. (1998) Juvenile arthritis, HLA-A2 and binding of DEK oncogene-peptides. Hum Immunol 59:443-50
Zwirner, N W; Fernandez-Vina, M A; Stastny, P (1998) MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes. Immunogenetics 47:139-48
Wang, J; Fernandez-Vina, M A; Lazaro, A M et al. (1997) New alleles of the HLA-B15 family. Hum Immunol 55:184-9
Boackle, S A; Holers, V M; Karp, D R (1997) CD21 augments antigen presentation in immune individuals. Eur J Immunol 27:122-9
Marcos, C Y; Fernandez-Vina, M A; Lazaro, A M et al. (1997) Novel HLA-B35 subtypes: putative gene conversion events with donor sequences from alleles common in native Americans (HLA-B*4002 or B*4801). Hum Immunol 53:148-55
Fernandez-Vina, M A; Lazaro, A M; Marcos, C Y et al. (1997) Dissimilar evolution of B-locus versus A-locus and class II loci of the HLA region in South American Indian tribes. Tissue Antigens 50:233-50