Despite the important contributions of both epidemiologic and basic science research during the past decade, important gaps exist in our current understanding of both the natural history and pathogenesis of HIV infection. Most recently, the substantial clinical efficiency of protease inhibitors has clearly been shown to extent significantly disease-free survival and death, as a result of dramatic reductions in HIV viral load. However, the exact virologic changes and immunological mechanisms which contribute to long-term survival are still unknown. We therefore propose to continue the Pittsburgh portion of the MACS by further intensive follow-up of a selected, HIV-infected cohort in order to further scientific understanding of the natural history and pathogenesis of HIV infection. The specific objectives and research plan emphasize the cohort-maintenance and biological specimen procurement aspects of the proposed continuation of the Pittsburgh MACS. Additional specific aims will focus on the strengths of the Pittsburgh investigators through collaborations in the areas of HIV viral load dynamics, HIV-specific cellular immune responses, sexual transmission dynamics and the newly identified lipodystrophy associated with HAART treatment modalities. We also propose to provide the MACS-wide coordination of the malignancy/autopsy program in order to investigate the incidence and determinants of cancer in HIV-infected gay/bisexual men. This includes storage of all MACS autopsies, SNOMED coding and distribution of autopsy tissue for research proposals to MACS and non- MACS investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI035041-10
Application #
6510612
Study Section
Special Emphasis Panel (ZAI1-KWR-A (J1))
Program Officer
Williams, Carolyn F
Project Start
1993-04-01
Project End
2004-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
10
Fiscal Year
2002
Total Cost
$2,748,094
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Public Health
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786
Wu, Minjie; Fatukasi, Omalara; Yang, Shaolin et al. (2018) HIV disease and diabetes interact to affect brain white matter hyperintensities and cognition. AIDS 32:1803-1810
Armstrong, Nicole M; Surkan, Pamela J; Treisman, Glenn J et al. (2018) Optimal metrics for identifying long term patterns of depression in older HIV-infected and HIV-uninfected men who have sex with men. Aging Ment Health :1-8
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Tibuakuu, Martin; Zhao, Di; Saxena, Ankita et al. (2018) Low thigh muscle mass is associated with coronary artery stenosis among HIV-infected and HIV-uninfected men: The Multicenter AIDS Cohort Study (MACS). J Cardiovasc Comput Tomogr 12:131-138
Maki, Pauline M; Rubin, Leah H; Springer, Gayle et al. (2018) Differences in Cognitive Function Between Women and Men With HIV. J Acquir Immune Defic Syndr 79:101-107
Dutta, Anupriya; Uno, Hajime; Lorenz, David R et al. (2018) Low T-cell subsets prior to development of virus-associated cancer in HIV-seronegative men who have sex with men. Cancer Causes Control 29:1131-1142
Martin, Maureen P; Naranbhai, Vivek; Shea, Patrick R et al. (2018) Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. J Clin Invest 128:1903-1912
Yanik, Elizabeth L; Hernández-Ramírez, Raúl U; Qin, Li et al. (2018) Brief Report: Cutaneous Melanoma Risk Among People With HIV in the United States and Canada. J Acquir Immune Defic Syndr 78:499-504

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