Abstract

Human neurocysticercosis affects millions of people in Latin America, Africa, and Asia, and is also present in developing countries with high immigration rates. This zoonotic disease is the major cause of acquired epilepsy in most of the world, and raises two- to four-fold the rates of epilepsy in endemic zones. Improvement of serological and imagenological diagnostic techniques, including the introduction by our group of the EITB-C (enzyme-linked immunoelectrotransfer blot assay) led to important advances in epidemiology and clinical management of Cysticerosis in the last ten years. The central theme of this project to complete development and improve the performance of he EITB-C and EITB-T, tests for Cysticerosis and taeniasis, respectively. These tests and their field versions will provide a set of critical and practical tools for patient identification, location, and management. When coupled with GPS data, these data should help us to better understand the transmission dynamics of Cysticerosis. Finally, when use in sentinal pigs, the EITB-C and its field version will allow us to accurately measure the efficacy of control projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI035894-07
Application #
6352597
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
7
Fiscal Year
2000
Total Cost
$88,075
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Gonzales, Isidro; Miranda, J Jaime; Rodriguez, Silvia et al. (2015) Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study. Trop Med Int Health 20:546-52
Arriola, Carmen S; Gonzalez, Armando E; Gomez-Puerta, Luis A et al. (2014) New insights in cysticercosis transmission. PLoS Negl Trop Dis 8:e3247
Gavidia, Cesar M; Verastegui, Manuela R; Garcia, Hector H et al. (2013) Relationship between serum antibodies and Taenia solium larvae burden in pigs raised in field conditions. PLoS Negl Trop Dis 7:e2192
O'Neal, Seth E; Moyano, Luz M; Ayvar, Viterbo et al. (2012) Geographic correlation between tapeworm carriers and heavily infected cysticercotic pigs. PLoS Negl Trop Dis 6:e1953
Gavidia, Cesar M; Gonzalez, Armando E; Barron, Eduardo A et al. (2010) Evaluation of oxfendazole, praziquantel and albendazole against cystic echinococcosis: a randomized clinical trial in naturally infected sheep. PLoS Negl Trop Dis 4:e616
Uddin, Jasim; Gonzalez, Armando E; Gilman, Robert H et al. (2010) Mechanisms regulating monocyte CXCL8 secretion in neurocysticercosis and the effect of antiparasitic therapy. J Immunol 185:4478-84
Sheen, Patricia; Ferrer, Patricia; Gilman, Robert H et al. (2009) Effect of pyrazinamidase activity on pyrazinamide resistance in Mycobacterium tuberculosis. Tuberculosis (Edinb) 89:109-13
Lescano, Andres G; Garcia, Hector H; Gilman, Robert H et al. (2009) Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures. PLoS Negl Trop Dis 3:e371
Villarán, Manuel V; Montano, Silvia M; Gonzalvez, Guillermo et al. (2009) Epilepsy and neurocysticercosis: an incidence study in a Peruvian rural population. Neuroepidemiology 33:25-31
Gavidia, Cesar M; Gonzalez, Armando E; Lopera, Luis et al. (2009) Evaluation of nitazoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep. Am J Trop Med Hyg 80:367-72

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