Tuberculosis control can be improved by targeting specific measures to specific populations. Chemoprophylaxis is the most efficient intervention for populations in which disease results from reactivated latent infection. Whereas case finding and treatment is more appropriate for those with considerable ongoing transmission. Currently, these measures are allocated based on the degree of, development of a country. Chemoprophylaxis used in developed countries and case finding in developing countries. In San Francisco we have integrated DNA fingerprinting techniques with conventional epidemiologic investigations to distinguish between reactivated and recently transmitted tuberculosis. In addition to targeting control strategies, this approach has yielded useful insights into the detailed epidemiology of tuberculosis transmission. We now propose to use this molecular approach to describe the epidemiology of transmitted and reactivated disease in the State of Chiapas, which has a tuberculosis rate that is almost three times greater than the Mexican national average. This approach should permit the precise targeting of these two basic control measures to specific subpopulations. In addition, detailed investigation of those patients who have been recently infected with tuberculosis will identify modifiable risk factors for tuberculosis transmission in tropical and developing regions of the world where tuberculosis is a major public health problem. Additionally, it is anticipated that this collaborative effort between basic scientists, clinicians, epidemiologists and public health officials from Chiapas, Mexico City, and the United States will result in the transfer of appropriate technologies to Mexico and strengthen tuberculosis control.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01AI035969-01
Application #
2071973
Study Section
Special Emphasis Panel (SRC (37))
Project Start
1994-06-01
Project End
1999-02-28
Budget Start
1994-06-01
Budget End
1995-02-28
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Stanford University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Bonacci, Robert A; Cruz-Hervert, Luis Pablo; García-García, Lourdes et al. (2013) Impact of cigarette smoking on rates and clinical prognosis of pulmonary tuberculosis in Southern Mexico. J Infect 66:303-12
Jimenez-Corona, M-E; Garcia-Garcia, L; DeRiemer, K et al. (2006) Gender differentials of pulmonary tuberculosis transmission and reactivation in an endemic area. Thorax 61:348-53
Garcia-Sancho F, Ma Cecilia; Garcia-Garcia, Lourdes; Jimenez-Corona, Ma Eugenia et al. (2006) Is tuberculin skin testing useful to diagnose latent tuberculosis in BCG-vaccinated children? Int J Epidemiol 35:1447-54
DeRiemer, Kathryn; Garcia-Garcia, Lourdes; Bobadilla-del-Valle, Miriam et al. (2005) Does DOTS work in populations with drug-resistant tuberculosis? Lancet 365:1239-45
Jacobson, Lara M; de Lourdes Garcia-Garcia, Ma; Hernandez-Avila, Juan Eugenio et al. (2005) Changes in the geographical distribution of tuberculosis patients in Veracruz, Mexico, after reinforcement of a tuberculosis control programme. Trop Med Int Health 10:305-11
del Campo-Rodriguez, Lucio Eduardo Martin; Sifuentes-Osornio, Jose (2004) [Opportunistic infections in the acquired inmunodeficiency syndrome: the history in Mexico 20 years after the beginning of the epidemic] Rev Invest Clin 56:169-80
Banaiee, Niaz; Bobadilla-del-Valle, Miriam; Riska, Paul F et al. (2003) Rapid identification and susceptibility testing of Mycobacterium tuberculosis from MGIT cultures with luciferase reporter mycobacteriophages. J Med Microbiol 52:557-61
Kivi, Marten; Liu, Xuemin; Raychaudhuri, Soumya et al. (2002) Determining the genomic locations of repetitive DNA sequences with a whole-genome microarray: IS6110 in Mycobacterium tuberculosis. J Clin Microbiol 40:2192-8
Porco, T C; Small, P M; Blower, S M (2001) Amplification dynamics: predicting the effect of HIV on tuberculosis outbreaks. J Acquir Immune Defic Syndr 28:437-44
Banaiee, N; Bobadilla-Del-Valle, M; Bardarov Jr, S et al. (2001) Luciferase reporter mycobacteriophages for detection, identification, and antibiotic susceptibility testing of Mycobacterium tuberculosis in Mexico. J Clin Microbiol 39:3883-8

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