Abstract

The appropriate methods of cancer screening and prevention in carriers of breast cancer predisposition gene mutations are unknown. We propose to conduct an observational study of mutation carriers to determine current screening practices. We will also determine the effect of prophylactic oophorectomy on the risk of ovarian/peritoneal cancer. This study will promote a collaborative effector between the Cooperative Family Registry for Breast Cancer Studies and wider research community and will provide subjects and an infrastructure for conductive definitive studies of breast and ovarian cancer screening and prevention.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01CA069446-07
Application #
6481751
Study Section
Special Emphasis Panel (ZCA1)
Project Start
1995-09-30
Project End
2005-11-30
Budget Start
Budget End
Support Year
7
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Dite, Gillian S; MacInnis, Robert J; Bickerstaffe, Adrian et al. (2017) Testing for Gene-Environment Interactions Using a Prospective Family Cohort Design: Body Mass Index in Early and Later Adulthood and Risk of Breast Cancer. Am J Epidemiol 185:487-500
Dite, Gillian S; MacInnis, Robert J; Bickerstaffe, Adrian et al. (2016) Breast Cancer Risk Prediction Using Clinical Models and 77 Independent Risk-Associated SNPs for Women Aged Under 50 Years: Australian Breast Cancer Family Registry. Cancer Epidemiol Biomarkers Prev 25:359-65
Piccolo, Stephen R; Hoffman, Laura M; Conner, Thomas et al. (2016) Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility. Mol Syst Biol 12:860
Piccolo, Stephen R; Andrulis, Irene L; Cohen, Adam L et al. (2015) Gene-expression patterns in peripheral blood classify familial breast cancer susceptibility. BMC Med Genomics 8:72
Antoniou, Antonis C; Casadei, Silvia; Heikkinen, Tuomas et al. (2014) Breast-cancer risk in families with mutations in PALB2. N Engl J Med 371:497-506
Ferris, J S; Daly, M B; Buys, S S et al. (2014) Oral contraceptive and reproductive risk factors for ovarian cancer within sisters in the breast cancer family registry. Br J Cancer 110:1074-80
Couch, Fergus J (see original citation for additional authors) (2013) Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet 9:e1003212
Nickels, Stefan; Truong, Thérèse; Hein, Rebecca et al. (2013) Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors. PLoS Genet 9:e1003284
Teo, Z L; Provenzano, E; Dite, G S et al. (2013) Tumour morphology predicts PALB2 germline mutation status. Br J Cancer 109:154-63
Zhang, Fang Fang; John, Esther M; Knight, Julia A et al. (2013) Total energy intake and breast cancer risk in sisters: the Breast Cancer Family Registry. Breast Cancer Res Treat 137:541-51

Showing the most recent 10 out of 57 publications