Abstract

The appropriate methods of cancer screening and prevention in carriers of breast cancer predisposition gene mutations are unknown. We propose to conduct an observational study of mutation carriers to determine current screening practices. We will also determine the effect of prophylactic oophorectomy on the risk of ovarian/peritoneal cancer. This study will promote a collaborative effector between the Cooperative Family Registry for Breast Cancer Studies and wider research community and will provide subjects and an infrastructure for conductive definitive studies of breast and ovarian cancer screening and prevention.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01CA069446-07
Application #
6481751
Study Section
Special Emphasis Panel (ZCA1)
Project Start
1995-09-30
Project End
2005-11-30
Budget Start
Budget End
Support Year
7
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Dite, Gillian S; MacInnis, Robert J; Bickerstaffe, Adrian et al. (2017) Testing for Gene-Environment Interactions Using a Prospective Family Cohort Design: Body Mass Index in Early and Later Adulthood and Risk of Breast Cancer. Am J Epidemiol 185:487-500
Dite, Gillian S; MacInnis, Robert J; Bickerstaffe, Adrian et al. (2016) Breast Cancer Risk Prediction Using Clinical Models and 77 Independent Risk-Associated SNPs for Women Aged Under 50 Years: Australian Breast Cancer Family Registry. Cancer Epidemiol Biomarkers Prev 25:359-65
Piccolo, Stephen R; Hoffman, Laura M; Conner, Thomas et al. (2016) Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility. Mol Syst Biol 12:860
Piccolo, Stephen R; Andrulis, Irene L; Cohen, Adam L et al. (2015) Gene-expression patterns in peripheral blood classify familial breast cancer susceptibility. BMC Med Genomics 8:72
Ferris, J S; Daly, M B; Buys, S S et al. (2014) Oral contraceptive and reproductive risk factors for ovarian cancer within sisters in the breast cancer family registry. Br J Cancer 110:1074-80
Antoniou, Antonis C; Casadei, Silvia; Heikkinen, Tuomas et al. (2014) Breast-cancer risk in families with mutations in PALB2. N Engl J Med 371:497-506
Dite, Gillian S; Mahmoodi, Maryam; Bickerstaffe, Adrian et al. (2013) Using SNP genotypes to improve the discrimination of a simple breast cancer risk prediction model. Breast Cancer Res Treat 139:887-96
Gracia-Aznarez, Francisco Javier; Fernandez, Victoria; Pita, Guillermo et al. (2013) Whole exome sequencing suggests much of non-BRCA1/BRCA2 familial breast cancer is due to moderate and low penetrance susceptibility alleles. PLoS One 8:e55681
Gaudet, Mia M; Kuchenbaecker, Karoline B; Vijai, Joseph et al. (2013) Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet 9:e1003173
Mocci, Evelina; Milne, Roger L; Méndez-Villamil, Elena Yuste et al. (2013) Risk of pancreatic cancer in breast cancer families from the breast cancer family registry. Cancer Epidemiol Biomarkers Prev 22:803-11

Showing the most recent 10 out of 57 publications