The long term goal of this proposal by the Ontario Family Registry (OFR) is to participate as part of the CFRBCS to complete the establishment of a hypothesis-driven interdisciplinary research platform to support, expedite and implement research in genetic epidemiology of breast cancer. The OFR contains a population-based cohort of breast cancer cases, identified as incident cases from the Ontario Cancer Registry from 1996 to 1998, and their families. In addition, the OFR contains prevalent AJ cases and their families recruited at familial cancer clinics. We have developed an extensive system for the identification of population-based incident breast cancer cases and the collection of family history, epidemiologic information, blood, and tissue specimens.
The specific aims of the renewal of the ORF are: 1) To enhance the value of the OFR by completing the collection of data and biospecimens from probands, extending the collection of data and biospecimens from relatives and recruiting additional subjects (minorities and Ashkenazim Jewish) into the OFR 2) To maintain a functioning OFR database and biospecimen repository 3) To participate in a broad spectrum of scientific studies, including clinical, pathological, gene discovery, gene-environment, genetic modifiers, and psycho-social. 4) To provide a resource for collaborative studies involving the CFRBCS sites and external collaborators This information will lead to an improved understanding of the contributions made to the etiology of breast cancer by genetic and environmental factors, to identify the factors, responsible, and to gain an understanding of how they act, both separately and together, to influence breast cancer risk.
| Dite, Gillian S; MacInnis, Robert J; Bickerstaffe, Adrian et al. (2017) Testing for Gene-Environment Interactions Using a Prospective Family Cohort Design: Body Mass Index in Early and Later Adulthood and Risk of Breast Cancer. Am J Epidemiol 185:487-500 |
| Barrdahl, Myrto; Rudolph, Anja; Hopper, John L et al. (2017) Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium. Int J Cancer 141:1830-1840 |
| Dite, Gillian S; MacInnis, Robert J; Bickerstaffe, Adrian et al. (2016) Breast Cancer Risk Prediction Using Clinical Models and 77 Independent Risk-Associated SNPs for Women Aged Under 50 Years: Australian Breast Cancer Family Registry. Cancer Epidemiol Biomarkers Prev 25:359-65 |
| Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, and Consortium of Modifiers of BRCA1 and BRCA2 (see original citation for additional authors) (2016) No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer. Gynecol Oncol 141:386-401 |
| Southey, Melissa C (see original citation for additional authors) (2016) PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS. J Med Genet 53:800-811 |
| Lin, Wei-Yu (see original citation for additional authors) (2015) Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk. Hum Mol Genet 24:285-98 |
| Rudolph, Anja; Milne, Roger L; Truong, Thérèse et al. (2015) Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors. Int J Cancer 136:E685-96 |
| Sawyer, Elinor; Roylance, Rebecca; Petridis, Christos et al. (2014) Genetic predisposition to in situ and invasive lobular carcinoma of the breast. PLoS Genet 10:e1004285 |
| Khan, Sofia; Greco, Dario; Michailidou, Kyriaki et al. (2014) MicroRNA related polymorphisms and breast cancer risk. PLoS One 9:e109973 |
| Antoniou, Antonis C; Casadei, Silvia; Heikkinen, Tuomas et al. (2014) Breast-cancer risk in families with mutations in PALB2. N Engl J Med 371:497-506 |
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