This proposal is for the Comprehensive Cancer Center Biostatistics Unit at the University of Alabama at Birmingham (UAB) to serve as the Operations, Statistical and Data Management Center for the AIDS-Associated Malignancies Clinical Trials Consortium (AMC). To date, the AMC has enrolled 159 patients on five AMC protocols. Two protocols have recently opened to patient accrual. An additional 9 protocols are under development. The AMC Operations Center provides statistical expertise to the AMC in the areas to study design, sample size, and analyses; coordinates the development, submission, conduct and analysis of AMC; maintains the database for the clinical trials; performs statistical analyses on study data; manages the Discretionary Fund; and coordinates the acquisition of specimens from AMC participants for donation to the AIDS Malignancy Bank. During the upcoming funding period, the AMC Operations Center plans to increase the use of scanners in the data entry process; increase the level of biostatistical support; increase the use of the AMC WEB page for the dissemination of information; and add a fiscal associate to the staff to manage the discretionary fund.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01CA070019-09S2
Application #
7116612
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Bhatia, Kishor
Project Start
1995-09-30
Project End
2007-05-31
Budget Start
2003-08-01
Budget End
2007-05-31
Support Year
9
Fiscal Year
2005
Total Cost
$671,113
Indirect Cost
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Noy, Ariela; Lensing, Shelly Y; Moore, Page C et al. (2016) Plasmablastic lymphoma is treatable in the HAART era. A 10 year retrospective by the AIDS Malignancy Consortium. Leuk Lymphoma 57:1731-4
Lechowicz, Maryjo; Dittmer, Dirk P; Lee, Jeannette Y et al. (2009) Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid. Clin Infect Dis 49:1946-9
Lin, Lan; Lee, Jeannette Y; Kaplan, Lawrence D et al. (2009) Effects of chemotherapy in AIDS-associated non-Hodgkin's lymphoma on Kaposi's sarcoma herpesvirus DNA in blood. J Clin Oncol 27:2496-502
van der Burg, Sjoerd H; Palefsky, Joel M (2009) Human Immunodeficiency Virus and Human Papilloma Virus - why HPV-induced lesions do not spontaneously resolve and why therapeutic vaccination can be successful. J Transl Med 7:108
Ratner, Lee; Harrington, William; Feng, Xuan et al. (2009) Human T cell leukemia virus reactivation with progression of adult T-cell leukemia-lymphoma. PLoS One 4:e4420
Spitzer, Thomas R; Ambinder, Richard F; Lee, Jeannette Y et al. (2008) Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium study 020. Biol Blood Marrow Transplant 14:59-66
Brinker, Brett T; Krown, Susan E; Lee, Jeannette Y et al. (2008) Phase 1/2 trial of BMS-275291 in patients with human immunodeficiency virus-related Kaposi sarcoma: a multicenter trial of the AIDS Malignancy Consortium. Cancer 112:1083-8
Stier, Elizabeth A; Goldstone, Stephen E; Berry, J Michael et al. (2008) Infrared coagulator treatment of high-grade anal dysplasia in HIV-infected individuals: an AIDS malignancy consortium pilot study. J Acquir Immune Defic Syndr 47:56-61
Noy, Ariela; von Roenn, Jamie; Politsmakher, Alex et al. (2007) Fatal hepatorenal failure and thrombocytopenia with SU5416, a vascular endothelial growth factor Flk-1 receptor inhibitor, in AIDS-Kaposi's sarcoma. AIDS 21:113-5
Krown, Susan E; Lee, Jeannette Y; Lin, Lan et al. (2006) Interferon-alpha2b with protease inhibitor-based antiretroviral therapy in patients with AIDS-associated Kaposi sarcoma: an AIDS malignancy consortium phase I trial. J Acquir Immune Defic Syndr 41:149-53

Showing the most recent 10 out of 20 publications