) Emerging scientific technologies that explore early cancer detection and assessment are of paramount importance in the effort toward reducing mortality from cancer. However, the approach to the development of biomarkers for early cancer detection bas been fragmented and not well coordinated. The charge of the Early Detection Research Network (EDRN) is to discover and coordinate the evaluation of biomarkers/reagents for the early detection of cancer and for the assessment of risk through scientific collaboration, knowledge sharing, and overall coordination of activities. The overall aim of the proposed Data Management and Coordinating Center (DMCC) is to provide coordination and data management for the EDRN under the direction of the Steering Committee, and to develop statistical and analytical methods useful for basic, translational, and clinical research in biomarkers for early detection of cancer. Under the direction of the Steering Committee, the DMCC will 1) perform network coordination and develop collaborations with other scientific components of the network by producing the Network Operations Policy and Procedure Manuals, assisting in the development and implementation of collaborative study research protocols, analyzing data from collaborative studies and providing statistical consultation for center-specific studies in EDRN, developing and maintaining a web page and listserv, promoting interactions between the EDRN and other relevant networks and consortia, and providing logistical and administrative support for network meetings; 2) provide data management support for collaborative studies in EDRN by developing data collection protocols and monitoring adherence, developing and maintaining collaborative study databases, and providing reports and study data as needed; 3) develop statistical and analytical methods for biomarker evaluation and interpretation, with emphasis on flexible descriptive statistical methods for a) assessing the reliability and reproducibility of biomarkers and identifying factors which contribute to reduced reliability; b) assessing the accuracy of biomarkers for cancer detection or cancer risk assessment, and factors influencing their diagnostic potential both when a gold standard exists and when it does not exist; c) combining multiple biomarkers; d) identifying cancer heterogeneity by biomarkers; and e) identifying biomarkers; from microarray expression data.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01CA086368-04S3
Application #
6789771
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Srivastava, Sudhir
Project Start
2000-04-14
Project End
2005-02-28
Budget Start
2003-04-18
Budget End
2004-02-29
Support Year
4
Fiscal Year
2003
Total Cost
$204,622
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Tayob, Nabihah; Stingo, Francesco; Do, Kim-Anh et al. (2018) A Bayesian screening approach for hepatocellular carcinoma using multiple longitudinal biomarkers. Biometrics 74:249-259
Liu, Dandan; Cai, Tianxi; Lok, Anna et al. (2018) Nonparametric Maximum Likelihood Estimators of Time-Dependent Accuracy Measures for Survival Outcome Under Two-Stage Sampling Designs. J Am Stat Assoc 113:882-892
Fu, Rong; Wang, Pei; Ma, Weiping et al. (2017) A statistical method for detecting differentially expressed SNVs based on next-generation RNA-seq data. Biometrics 73:42-51
Zheng, Yingye; Brown, Marshall; Lok, Anna et al. (2017) IMPROVING EFFICIENCY IN BIOMARKER INCREMENTAL VALUE EVALUATION UNDER TWO-PHASE DESIGNS. Ann Appl Stat 11:638-654
Maziarz, Marlena; Heagerty, Patrick; Cai, Tianxi et al. (2017) On longitudinal prediction with time-to-event outcome: Comparison of modeling options. Biometrics 73:83-93
Zhou, Qian M; Dai, Wei; Zheng, Yingye et al. (2017) Robust Dynamic Risk Prediction with Longitudinal Studies. Stat Theory Relat Fields 1:159-170
Kundu, Madan G; Harezlak, Jaroslaw; Randolph, Timothy W (2016) Longitudinal Functional Models with Structured Penalties. Stat Modelling 16:114-139
Tretiakova, M S; Wei, W; Boyer, H D et al. (2016) Prognostic value of Ki67 in localized prostate carcinoma: a multi-institutional study of >1000 prostatectomies. Prostate Cancer Prostatic Dis 19:264-70
Koopmeiners, Joseph S; Feng, Ziding (2016) Group sequential testing of the predictive accuracy of a continuous biomarker with unknown prevalence. Stat Med 35:1267-80
Huang, Ying; Laber, Eric (2016) Personalized Evaluation of Biomarker Value: A Cost-Benefit Perspective. Stat Biosci 8:43-65

Showing the most recent 10 out of 90 publications