In the first CISNET project we developed a population-based Monte Carlo simulation model that evaluates national trends in the incidence and mortality of colorectal cancer (CRC). The HSPH-CISNET Model incorporates age-, sex-, and race-specific trends in CRC risk factors, screening, and treatment, as well as the effects of risk factors and screening on the underlying natural history of colorectal disease and the effectiveness of treatment for patients with diagnosed CRC. The Model currently simulates the US population aged 25 years and older from 1970 to 2020. We have used the Model to examine the relative contribution of changes in risk factors, screening, and treatment to the overall population trends in CRC incidence and mortality. The purpose of this project is to use the HSPH-CISNET Model to evaluate the population impact of existing cancer control strategies, as well as the impact of strategies on the horizon. Of particular importance is to incorporate the associations between risk factors and screening trends, and to determine the potential impact of disparities in CRC risk and mortality at a population level.
Other aims will focus on evaluating the population-level impact of specific risk factor trends, screening modalities, and treatment advancements. To validate our modeling assumptions, we will use our model structure to simulate the population of Norway, a country that does not have a CRC screening program, in an attempt to re-create their incidence and mortality statistics. We will continue to collaborate with other modeling groups, as well as with the new CRC Coordinating Center and the NCI to focus on questions that apply across all modeling groups. In addition, we propose a concrete plan for making our model more accessible to outside collaborators. This plan involves posting the model structure on a public website, sharing code with established outside investigators, and providing the necessary model support.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01CA088204-09S1
Application #
8135088
Study Section
Special Emphasis Panel (ZCA1-SRRB-K (M1))
Program Officer
Stedman, Margaret R
Project Start
2000-09-01
Project End
2011-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
9
Fiscal Year
2010
Total Cost
$32,950
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Haug, Ulrike; Knudsen, Amy B; Lansdorp-Vogelaar, Iris et al. (2015) Development of new non-invasive tests for colorectal cancer screening: the relevance of information on adenoma detection. Int J Cancer 136:2864-74
Goede, Simon L; Kuntz, Karen M; van Ballegooijen, Marjolein et al. (2015) Cost-Savings to Medicare From Pre-Medicare Colorectal Cancer Screening. Med Care 53:630-8
Haug, Ulrike; Knudsen, Amy B; Kuntz, Karen M (2012) How should individuals with a false-positive fecal occult blood test for colorectal cancer be managed? A decision analysis. Int J Cancer 131:2094-102
Lansdorp-Vogelaar, Iris; Kuntz, Karen M; Knudsen, Amy B et al. (2012) Contribution of screening and survival differences to racial disparities in colorectal cancer rates. Cancer Epidemiol Biomarkers Prev 21:728-36
Knudsen, Amy B; Hur, Chin; Gazelle, G Scott et al. (2012) Rescreening of persons with a negative colonoscopy result: results from a microsimulation model. Ann Intern Med 157:611-20
Berrington de González, Amy; Kim, Kwang Pyo; Knudsen, Amy B et al. (2011) Radiation-related cancer risks from CT colonography screening: a risk-benefit analysis. AJR Am J Roentgenol 196:816-23
Vanness, David J; Knudsen, Amy B; Lansdorp-Vogelaar, Iris et al. (2011) Comparative economic evaluation of data from the ACRIN National CT Colonography Trial with three cancer intervention and surveillance modeling network microsimulations. Radiology 261:487-98
Kuntz, Karen M; Lansdorp-Vogelaar, Iris; Rutter, Carolyn M et al. (2011) A systematic comparison of microsimulation models of colorectal cancer: the role of assumptions about adenoma progression. Med Decis Making 31:530-9
Lansdorp-Vogelaar, Iris; Knudsen, Amy B; Brenner, Hermann (2011) Cost-effectiveness of colorectal cancer screening. Epidemiol Rev 33:88-100
van Ballegooijen, Marjolein; Rutter, Carolyn M; Knudsen, Amy B et al. (2011) Clarifying differences in natural history between models of screening: the case of colorectal cancer. Med Decis Making 31:540-9

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