Abstract

These proposed studies directly address 3 RFA objectives. First, we offer a basic/translational sciencestudy that considers local urogenital tract factors in the pathogenesis of UCPPS. Second, we address RFArequest for studies to identify and validate biomarkers for UCPPS. Our strategy uses cutting-edge proteomicanalysis of urine specimens from patients with IC/PBS and CP/CPPS in a new approach to identify andvalidate new biomarkers that potentially could improve diagnosis, predict UCPPS natural history, and predict ormeasure response to treatment. Third, this work also addresses the RFA priority to elucidate the pathogenesisof UCPPS. These protein/peptide markers may act via specific cellular pathways important to UCPPSpathology. Notably, if successful, this technology can be exported across the Network and could establish afoundation for future clinical trials and for more targeted therapies to treat specific urothelial defects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01DK082325-01
Application #
7570944
Study Section
Special Emphasis Panel (ZDK1-GRB-G (M1))
Project Start
2008-09-15
Project End
2013-06-30
Budget Start
2008-09-15
Budget End
2009-06-30
Support Year
1
Fiscal Year
2008
Total Cost
$130,016
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Schrepf, Andrew; Naliboff, Bruce; Williams, David A et al. (2018) Adverse Childhood Experiences and Symptoms of Urologic Chronic Pelvic Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study. Ann Behav Med 52:865-877
Sutcliffe, Siobhan; Jemielita, Thomas; Lai, H Henry et al. (2018) A Case-Crossover Study of Urological Chronic Pelvic Pain Syndrome Flare Triggers in the MAPP Research Network. J Urol 199:1245-1251
Yang, Claire C; Miller, Jane L; Omidpanah, Adam et al. (2018) Physical Examination for Men and Women With Urologic Chronic Pelvic Pain Syndrome: A MAPP (Multidisciplinary Approach to the Study of Chronic Pelvic Pain) Network Study. Urology 116:23-29
Clemens, J Quentin; Stephens-Shields, Alisa; Naliboff, Bruce D et al. (2018) Correlates of Health Care Seeking Activities in Patients with Urological Chronic Pelvic Pain Syndromes: Findings from the MAPP Cohort. J Urol 200:136-140
Naliboff, Bruce D; Stephens, Alisa J; Lai, H Henry et al. (2017) Clinical and Psychosocial Predictors of Urological Chronic Pelvic Pain Symptom Change in 1 Year: A Prospective Study from the MAPP Research Network. J Urol 198:848-857
Kutch, Jason J; Labus, Jennifer S; Harris, Richard E et al. (2017) Resting-state functional connectivity predicts longitudinal pain symptom change in urologic chronic pelvic pain syndrome: a MAPP network study. Pain 158:1069-1082
Kutch, Jason J; Ichesco, Eric; Hampson, Johnson P et al. (2017) Brain signature and functional impact of centralized pain: a multidisciplinary approach to the study of chronic pelvic pain (MAPP) network study. Pain 158:1979-1991
Godfrey, Kathryn M; Herbert, Matthew; Strachan, Eric et al. (2017) Dexamethasone-suppressed Salivary Cortisol and Pain Sensitivity in Female Twins. Clin J Pain 33:246-253
Gasperi, Marianna; Krieger, John N; Forsberg, Christopher et al. (2017) Chronic prostatitis and comorbid non-urological overlapping pain conditions: A co-twin control study. J Psychosom Res 102:29-33
Lai, H Henry; Jemielita, Thomas; Sutcliffe, Siobhan et al. (2017) Characterization of Whole Body Pain in Urological Chronic Pelvic Pain Syndrome at Baseline: A MAPP Research Network Study. J Urol 198:622-631

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