Abstract

This proposal is submitted in response to a Request for Application (RFA) NIH-86-HL-19-P entitled """"""""Diet Intervention in Children with High LDL: CRD. CTR. The proposed organization, budget, staffing, and methods and procedures relate to Phases I (feasibility study), II (full-scale trial) and III (analysis) and cover a time period of 7.0 years. This study is designed to assess the feasibility, acceptability, efficacy and safety of dietary intervention in children age 8-10 with elevated low density lipoprotein cholesterol levels. The interest in this age group is to allow examination off the issue of the safety of recommended dietary interventions during the years of most rapid growth and development. The purpose of the Coordinating Center with the Diet Intervention Study is to be responsible, in collaboration with the Steering Committee, for the design, conduct and analysis of both the feasibility study and the full-scale trial. The Coordinating Center will be located at Maryland Medical Research Institute in Baltimore, Maryland.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL037948-05
Application #
3552914
Study Section
Special Emphasis Panel (SRC (19))
Project Start
1986-12-04
Project End
1993-11-30
Budget Start
1991-02-11
Budget End
1992-01-31
Support Year
5
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Maryland Medical Research Institute, Inc
Department
Type
DUNS #
069392181
City
Baltimore
State
MD
Country
United States
Zip Code
21210

  Publications

Egleston, Brian L; Chandler, D Walt; Dorgan, Joanne F (2010) Validity of estimating non-sex hormone-binding globulin bound testosterone and oestradiol from total hormone measurements in boys and girls. Ann Clin Biochem 47:233-41
Albertson, Ann M; Affenito, Sandra G; Bauserman, Robert et al. (2009) The relationship of ready-to-eat cereal consumption to nutrient intake, blood lipids, and body mass index of children as they age through adolescence. J Am Diet Assoc 109:1557-65
Fang, Carolyn Y; Egleston, Brian L; Brown, Kathleen M et al. (2009) Family cohesion moderates the relation between free testosterone and delinquent behaviors in adolescent boys and girls. J Adolesc Health 44:590-7
Baer, Heather J; Colditz, Graham A; Willett, Walter C et al. (2007) Adiposity and sex hormones in girls. Cancer Epidemiol Biomarkers Prev 16:1880-8
Dorgan, Joanne F; McMahon, Robert P; Friedman, Lisa Aronson et al. (2006) Diet and sex hormones in boys: findings from the dietary intervention study in children. J Clin Endocrinol Metab 91:3992-6
Gidding, Samuel S; Barton, Bruce A; Dorgan, Joanne A et al. (2006) Higher self-reported physical activity is associated with lower systolic blood pressure: the Dietary Intervention Study in Childhood (DISC). Pediatrics 118:2388-93
Dorgan, Joanne F; Hunsberger, Sally A; McMahon, Robert P et al. (2003) Diet and sex hormones in girls: findings from a randomized controlled clinical trial. J Natl Cancer Inst 95:132-41
Obarzanek, E; Kimm, S Y; Barton, B A et al. (2001) Long-term safety and efficacy of a cholesterol-lowering diet in children with elevated low-density lipoprotein cholesterol: seven-year results of the Dietary Intervention Study in Children (DISC). Pediatrics 107:256-64
Lavigne, J V; Brown, K M; Gidding, S et al. (1999) A cholesterol-lowering diet does not produce adverse psychological effects in children: three-year results from the dietary intervention study in children. Health Psychol 18:604-13
Simons-Morton, D G; Hunsberger, S A; Van Horn, L et al. (1997) Nutrient intake and blood pressure in the Dietary Intervention Study in Children. Hypertension 29:930-6

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