Atherosclerosis begins in childhood. The extent and progression of atherosclerosis is related to low density lipoprotein (LDL) levels. LDL levels persist over time, but can be altered by diet. The overall aim is to investigate the efficacy, safety, feasibility and acceptability of dietary intervention in children with high LDL. A sample of children 8-10 years old with LDL cholesterol (C) greater than the 90th percentile will be selected from a representative sample of the children in the New Orleans Public and Catholic Schools. Initially, 20 children will enter a 16-month feasibility study. Later 80 children will enter a 3-4 year clinical trial. The children will be randomized to return to the usual medical care (UC) or to a special care (SC) diet intervention. The special care diet will be low in fat, saturated fat and cholesterol (Phase I of the American Heart Association). We will compare in UC and SC the changes in eating behavior, nutrient intake, nutritional status, lipids, lipoproteins, and examine the determinants of response to the diet and the impact on psychosocial function. The clinical trial will be conducted in collaboration with five other clinics and the NHLBI staff.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
7U01HL038110-05
Application #
3552975
Study Section
Special Emphasis Panel (SRC (17))
Project Start
1986-12-04
Project End
1993-05-31
Budget Start
1990-08-15
Budget End
1991-01-31
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Children's Hospital (New Orleans)
Department
Type
DUNS #
069523405
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Egleston, Brian L; Chandler, D Walt; Dorgan, Joanne F (2010) Validity of estimating non-sex hormone-binding globulin bound testosterone and oestradiol from total hormone measurements in boys and girls. Ann Clin Biochem 47:233-41
Albertson, Ann M; Affenito, Sandra G; Bauserman, Robert et al. (2009) The relationship of ready-to-eat cereal consumption to nutrient intake, blood lipids, and body mass index of children as they age through adolescence. J Am Diet Assoc 109:1557-65
Fang, Carolyn Y; Egleston, Brian L; Brown, Kathleen M et al. (2009) Family cohesion moderates the relation between free testosterone and delinquent behaviors in adolescent boys and girls. J Adolesc Health 44:590-7
Baer, Heather J; Colditz, Graham A; Willett, Walter C et al. (2007) Adiposity and sex hormones in girls. Cancer Epidemiol Biomarkers Prev 16:1880-8
Dorgan, Joanne F; McMahon, Robert P; Friedman, Lisa Aronson et al. (2006) Diet and sex hormones in boys: findings from the dietary intervention study in children. J Clin Endocrinol Metab 91:3992-6
Gidding, Samuel S; Barton, Bruce A; Dorgan, Joanne A et al. (2006) Higher self-reported physical activity is associated with lower systolic blood pressure: the Dietary Intervention Study in Childhood (DISC). Pediatrics 118:2388-93
Dorgan, Joanne F; Hunsberger, Sally A; McMahon, Robert P et al. (2003) Diet and sex hormones in girls: findings from a randomized controlled clinical trial. J Natl Cancer Inst 95:132-41
Obarzanek, E; Kimm, S Y; Barton, B A et al. (2001) Long-term safety and efficacy of a cholesterol-lowering diet in children with elevated low-density lipoprotein cholesterol: seven-year results of the Dietary Intervention Study in Children (DISC). Pediatrics 107:256-64