The bypass angioplasty revascularization investigaiton (BARI) is a prospective multicenter, randomized clinical trial of percutaneous transluminal coronary angioplasty (PTCA) compared to coronary artery bypass surgery (CABG). Patients with Canadian Class III or IV angina, and patients who are status-post myocardial infarction with suitable multivessel coronary artery disease will be randomized to receive PTCA or CABG. A 2 year recruitment and 5 year follow-up period will be required. The major endpoints for the trial will be mortality and myocardial infarction. In order to detect a difference between the interventions 2,000 patients will be randomized. Other outcomes which will be studied for these intervention inclued: 1) relief of angina, 2) rest and exercise left ventricular function, 3) completeness of revascularization, 4) recurrence rate, 5) corssover rate, 6) cost, 7) memory and cognitive abilities, and 8) quality of life. The date analysis will also focus on several important subsets including those patients: 1) status-post recent myocardial infarction, 2) age over 65 years, 3) proximal left anteriaor descending artery stenosis, 4) unstable angina 5) chronic total occlusion, and 6) imparied left ventricular function. The results of this trial are expected to help delineate the optimal application of the PTCA and CABG interventional strategies.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL038529-06
Application #
3553064
Study Section
Special Emphasis Panel (SRC (BA))
Project Start
1987-06-01
Project End
1994-11-30
Budget Start
1991-12-30
Budget End
1992-11-30
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Holmes Jr, David R; Kim, Lauren J; Brooks, Maria Mori et al. (2007) The effect of coronary artery bypass grafting on specific causes of long-term mortality in the Bypass Angioplasty Revascularization Investigation. J Thorac Cardiovasc Surg 134:38-46, 46.e1
BARI Investigators (2007) The final 10-year follow-up results from the BARI randomized trial. J Am Coll Cardiol 49:1600-6
Holper, Elizabeth M; Brooks, Maria Mori; Kim, Lauren J et al. (2007) Effects of heart failure and diabetes mellitus on long-term mortality after coronary revascularization (from the BARI Trial). Am J Cardiol 100:196-202
Kip, Kevin E; Alderman, Edwin L; Bourassa, Martial G et al. (2002) Differential influence of diabetes mellitus on increased jeopardized myocardium after initial angioplasty or bypass surgery: bypass angioplasty revascularization investigation. Circulation 105:1914-20
Schwartz, Leonard; Kip, Kevin E; Frye, Robert L et al. (2002) Coronary bypass graft patency in patients with diabetes in the Bypass Angioplasty Revascularization Investigation (BARI). Circulation 106:2652-8
Vander Salm, Thomas J; Kip, Kevin E; Jones, Robert H et al. (2002) What constitutes optimal surgical revascularization? Answers from the Bypass Angioplasty Revascularization Investigation (BARI). J Am Coll Cardiol 39:565-72
Bittner, Vera; Hardison, Regina; Kelsey, Sheryl F et al. (2002) Non-high-density lipoprotein cholesterol levels predict five-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI). Circulation 106:2537-42
Gurm, Hitinder S; Whitlow, Patrick L; Kip, Kevin E et al. (2002) The impact of body mass index on short- and long-term outcomes inpatients undergoing coronary revascularization. Insights from the bypass angioplasty revascularization investigation (BARI). J Am Coll Cardiol 39:834-40
Yokoyama, Y; Chaitman, B R; Hardison, R M et al. (2000) Association between new electrocardiographic abnormalities after coronary revascularization and five-year cardiac mortality in BARI randomized and registry patients. Am J Cardiol 86:819-24
Ellis, S G; Cowley, M J; Whitlow, P L et al. (1995) Prospective case-control comparison of percutaneous transluminal coronary revascularization in patients with multivessel disease treated in 1986-1987 versus 1991: improved in-hospital and 12-month results. Multivessel Angioplasty Prognosis Study (MAPS) Gr J Am Coll Cardiol 25:1137-42

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