Abstract

In this Core, we will ask the question: """"""""Does SNP stratification predict systemic therapeutic drug responses in large, prospective randomized, controlled USA clinical trials?"""""""" For this purpose, we have obtained access to two such clinical trials in hypertension and renal disease, wherein the therapeutic drug responses occur to a beta-adrenergic antagonist (metoprolol), an alpha-adrenergic antagonist (doxazosin), a calcium channel antagonist (amlodipine) ACE inhibitors (ramipril or lisinopril), or a diuretic (chlorthalidone).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01HL069758-01
Application #
6541445
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2001-09-13
Project End
2005-08-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Hightower, C Makena; Zhang, Kuixing; Miramontes-González, José P et al. (2013) Genetic variation at the delta-sarcoglycan (SGCD) locus elevates heritable sympathetic nerve activity in human twin pairs. J Neurochem 127:750-61
Papp, Audrey C; Pinsonneault, Julia K; Wang, Danxin et al. (2012) Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk. PLoS One 7:e31930
Davis, Jason T; Rao, Fangwen; Naqshbandi, Dalal et al. (2012) Autonomic and hemodynamic origins of pre-hypertension: central role of heredity. J Am Coll Cardiol 59:2206-16
Price, Elvin Tyrone; Pacanowski, Michael A; Martin, Michael A et al. (2011) Liver X receptor ? gene polymorphisms and variable cardiovascular outcomes in patients treated with antihypertensive therapy: results from the INVEST-GENES study. Pharmacogenet Genomics 21:333-40
Gong, Yan; Beitelshees, Amber L; Cooper-DeHoff, Rhonda M et al. (2011) Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease. Circ Cardiovasc Genet 4:169-78
Lobmeyer, Maximilian T; Wang, Liewei; Zineh, Issam et al. (2011) Polymorphisms in genes coding for GRK2 and GRK5 and response differences in antihypertensive-treated patients. Pharmacogenet Genomics 21:42-9
Gayen, Jiaur R; Zhang, Kuixing; RamachandraRao, Satish P et al. (2010) Role of reactive oxygen species in hyperadrenergic hypertension: biochemical, physiological, and pharmacological evidence from targeted ablation of the chromogranin a (Chga) gene. Circ Cardiovasc Genet 3:414-25
Niu, Yuxin; Gong, Yan; Langaee, Taimour Y et al. (2010) Genetic variation in the beta2 subunit of the voltage-gated calcium channel and pharmacogenetic association with adverse cardiovascular outcomes in the INternational VErapamil SR-Trandolapril STudy GENEtic Substudy (INVEST-GENES). Circ Cardiovasc Genet 3:548-55
Johnson, A D; Gong, Y; Wang, D et al. (2009) Promoter polymorphisms in ACE (angiotensin I-converting enzyme) associated with clinical outcomes in hypertension. Clin Pharmacol Ther 85:36-44
Gayen, Jiaur R; Saberi, Maziyar; Schenk, Simon et al. (2009) A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis. J Biol Chem 284:28498-509

Showing the most recent 10 out of 72 publications