? Out-of-hospital cardiopulmonary arrest (OOH-CA) and life-threatening traumatic injury (LTI), including traumatic brain injury, warrant joint investigation since they share several common features. A Data Coordinating Center for a Resuscitation Research Consortium will play a central role in conducting clinical trials in the area of OOH-CA and LTI. In order to do so, three specific aims are proposed: ? 1) To develop and implement a clinical trials consortium to simultaneously study patients with OOH-CA and LTI by providing collaboration, coordination, administration and support to regional clinical centers, sponsors and oversight bodies. ? 2) To develop and implement procedures to rapidly design and implement a series of high-quality randomized trials that have optimal internal and external validity. ? 3) To rapidly disseminate the methods and the results of these trials to the research and clinical practice community so as to improve resuscitation outcomes. ? In order to meet this aim, the Data Coordinating Center (DCC) will draw upon its extensive experience with community emergency service providers, emergency physicians and cardiologists to actively collaborate with highly-qualified clinicians interested in OOH-CA and LTI at each regional clinical center (RCC). The Consortium will develop and implement standard definitions for diagnosis, and assessment of structure, process, and outcome related to OOH-CA and LTI to characterize their natural history, and response to interventions. The Data Coordinating Center will enhance an existing interactive information technology system in collaboration with a technology partner to facilitate communication and development. In addition, rapid and bias-free methods of randomization will be implemented by using an innovative software and handheld solution that has been developed and pilot tested. Robust, secure and confidential methods of data management and quality control will be used to provide a central repository for timely acquisition of data, so that prompt careful analyses can be conducted. Multiple strategies will be used to ensure timely and effective uptake of study results by policy makers, practitioners, and the public in order to improve EMS-related health care delivery in the United States and Canada. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL077863-03
Application #
7095243
Study Section
Special Emphasis Panel (ZHL1-CSR-G (M1))
Program Officer
Sopko, George
Project Start
2004-09-01
Project End
2009-04-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
3
Fiscal Year
2006
Total Cost
$6,193,836
Indirect Cost
Name
University of Washington
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Wang, Henry E; Schmicker, Robert H; Daya, Mohamud R et al. (2018) Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. JAMA 320:769-778
Meyer, David E; Cotton, Bryan A; Fox, Erin E et al. (2018) A comparison of resuscitation intensity and critical administration threshold in predicting early mortality among bleeding patients: A multicenter validation in 680 major transfusion patients. J Trauma Acute Care Surg 85:691-696
Cardenas, Jessica C; Zhang, Xu; Fox, Erin E et al. (2018) Platelet transfusions improve hemostasis and survival in a substudy of the prospective, randomized PROPPR trial. Blood Adv 2:1696-1704
Greene, Thomas J; DeSantis, Stacia M; Fox, Erin E et al. (2018) Utilizing Propensity Score Analyses in Prehospital Blood Product Transfusion Studies: Lessons Learned and Moving Toward Best Practice. Mil Med 183:124-133
Cardenas, Jessica C; Wade, Charles E; Cotton, Bryan A et al. (2018) Teg Lysis Shutdown Represents Coagulopathy in Bleeding Trauma Patients: Analysis of the Proppr Cohort. Shock :
Pollack, Ross A; Weisfeldt, Myron L (2018) Response by Pollack and Weisfeldt to Letter Regarding Article, ""Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests"". Circulation 138:2732-2733
Pollack, Ross A; Brown, Siobhan P; Rea, Thomas et al. (2018) Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests. Circulation 137:2104-2113
Chang, Ronald; Fox, Erin E; Greene, Thomas J et al. (2018) Abnormalities of laboratory coagulation tests versus clinically evident coagulopathic bleeding: results from the prehospital resuscitation on helicopters study (PROHS). Surgery 163:819-826
Blewer, Audrey L; McGovern, Shaun K; Schmicker, Robert H et al. (2018) Gender Disparities Among Adult Recipients of Bystander Cardiopulmonary Resuscitation in the Public. Circ Cardiovasc Qual Outcomes 11:e004710
Robinson, Bryce R H; Cohen, Mitchell J; Holcomb, John B et al. (2018) Risk Factors for the Development of Acute Respiratory Distress Syndrome Following Hemorrhage. Shock 50:258-264

Showing the most recent 10 out of 166 publications