This application is a proposal to create a Collaborative Canadian Regional Clinical Center (RCC), with two major partners: the University of Ottawa/OPALS Study Group and the University of British Columbia Group. The overall goal of the proposed Collaborative Canadian RCC is to continue to conduct large resuscitation clinical trials that will improve the outcomes of victims of cardiopulmonary arrest and major trauma. As a major partner in the Consortium, the Collaborative Canadian RCC commits to achieving all objectives of the Consortium with regards to cardiopulmonary arrest and major trauma. a) Conduct large, collaborative clinical trials to evaluate interventions that will improve survival; b) Strengthen existing research infrastructure in Ottawa/OPALS and British Columbia groups; c) Produce methodologically robust research proposals for the Consortium; d) Strengthen and further develop regional and national cardiopulmonary arrest and trauma registries; e) Support potential emerging sites for resuscitation research in Canada (Cities of Calgary and Edmonton and Province of Nova Scotia); f) Facilitate the training of clinical researchers in resuscitation and emergency medicine through a Clinical Research Skills Development Core. In particular, the proposed Collaborative Canadian RCC has designed two specific resuscitation randomized controlled clinical trials for cardiopulmonary arrest and major trauma. a) A Comparison of Fixed Versus Escalating Energy Regimens for Biphasic Waveform Defibrillation. This trial will compare the effect of fixed low-level energy (150 joules) to escalating energy (200-300-360 joules) regimens on the clinical outcomes of out-of-hospital cardiopulmonary arrest patients. b) Prehospital Intubation and Ventilation Control in Blunt Head Injury. This trial will compare prehospital mandatory Rapid Sequence Intubation followed by controlled ventilation to Standard Airway management in trauma patients with head injury and decreased level of consciousness.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL077885-04
Application #
7276737
Study Section
Special Emphasis Panel (ZHL1-CSR-G (M1))
Program Officer
Sopko, George
Project Start
2004-07-01
Project End
2009-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
4
Fiscal Year
2007
Total Cost
$172,495
Indirect Cost
Name
Ottawa Hospital Research Institute
Department
Type
DUNS #
201768095
City
Ottawa
State
ON
Country
Canada
Zip Code
K1 4-E9
Pollack, Ross A; Brown, Siobhan P; Rea, Thomas et al. (2018) Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests. Circulation 137:2104-2113
Blewer, Audrey L; McGovern, Shaun K; Schmicker, Robert H et al. (2018) Gender Disparities Among Adult Recipients of Bystander Cardiopulmonary Resuscitation in the Public. Circ Cardiovasc Qual Outcomes 11:e004710
Hansen, Matthew; Schmicker, Robert H; Newgard, Craig D et al. (2018) Time to Epinephrine Administration and Survival From Nonshockable Out-of-Hospital Cardiac Arrest Among Children and Adults. Circulation 137:2032-2040
Brooks, Steven C; Schmicker, Robert H; Cheskes, Sheldon et al. (2017) Variability in the initiation of resuscitation attempts by emergency medical services personnel during out-of-hospital cardiac arrest. Resuscitation 117:102-108
Morrison, Laurie J; Devlin, Sean M; Kontos, Michael C et al. (2017) The association of maximum Troponin values post out-of-hospital cardiac arrest with electrocardiographic findings, cardiac reperfusion procedures and survival to discharge: A sub-study of ROC PRIMED. Resuscitation 111:82-89
Salcido, David D; Schmicker, Robert H; Buick, Jason E et al. (2017) Compression-to-ventilation ratio and incidence of rearrest-A secondary analysis of the ROC CCC trial. Resuscitation 115:68-74
Drennan, Ian R; Case, Erin; Verbeek, P Richard et al. (2017) A comparison of the universal TOR Guideline to the absence of prehospital ROSC and duration of resuscitation in predicting futility from out-of-hospital cardiac arrest. Resuscitation 111:96-102
Kudenchuk, Peter J; Leroux, Brian G; Daya, Mohamud et al. (2017) Antiarrhythmic Drugs for Nonshockable-Turned-Shockable Out-of-Hospital Cardiac Arrest: The ALPS Study (Amiodarone, Lidocaine, or Placebo). Circulation 136:2119-2131
Grunau, Brian; Taylor, John; Scheuermeyer, Frank X et al. (2017) External Validation of the Universal Termination of Resuscitation Rule for Out-of-Hospital Cardiac Arrest in British Columbia. Ann Emerg Med 70:374-381.e1
Wang, Henry E; Prince, David K; Drennan, Ian R et al. (2017) Post-resuscitation arterial oxygen and carbon dioxide and outcomes after out-of-hospital cardiac arrest. Resuscitation 120:113-118

Showing the most recent 10 out of 96 publications